Cocaine Use Disorder Clinical Trial
Official title:
Phase 1, Double-Blind, Placebo-Controlled, Parallel Group Study to Assess Potential Interactions Between Intravenous Cocaine and Oral STP7
This is a double-blind, placebo-controlled, parallel group study to compare the effects of STP7 (mavoglurant) vs placebo control on i.v. cocaine's physiological and subjective effects in non-treatment seeking, cocaine-experienced males or females participants between 18 and 59 years of age. The primary objective of this study is to determine if there are clinically meaningful interactions between oral STP7 (mavoglurant) treatment concurrent with 20 and 40 mg i.v. cocaine infusions by measuring adverse events and cardiovascular responses including heart rate, blood pressure, and electrocardiogram (including corrected QT interval). The secondary objectives are: - To evaluate whether administration of STP7 (mavoglurant) alters the pharmacokinetics of cocaine and/or its major metabolite, benzoylecgonine. - To determine the pharmacokinetic of STP7 (mavoglurant) administered at a dose of 200 mg twice a day. - To evaluate whether STP7 (mavoglurant) treatment alters the subjective effects of cocaine measured by Visual Analog Scales (VAS) and Brief Substance Craving Scale (BSCS).
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03538548 -
Treatment Outcome in CBT for Cocaine Use
|
N/A | |
| Recruiting |
NCT04994821 -
tDCS to Reduce Craving in Cocaine Addiction- Phase 2 Study
|
Phase 2 | |
| Not yet recruiting |
NCT06050304 -
CRACK-TARGET 1: ÉTUDE DESCRIPTIVE DE LA SENSIBILISATION COMPORTEMENTALE OBSERVÉE et ATTENTES
|
||
| Completed |
NCT02233647 -
Phendimetrazine and Cocaine
|
Early Phase 1 | |
| Completed |
NCT02239913 -
Topiramate-Phentermine Combinations for Cocaine Dependence
|
Phase 1 | |
| Not yet recruiting |
NCT05974202 -
rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder
|
Phase 2 | |
| Recruiting |
NCT04927143 -
Encouraging Abstinence Behavior in a Drug Epidemic
|
Phase 2 | |
| Completed |
NCT03224546 -
Cocaine Use Reduction and Health
|
N/A | |
| Recruiting |
NCT03656653 -
Imagery-based Coping for Cocaine Use Disorder
|
N/A | |
| Completed |
NCT03348384 -
[11C]NOP-1A and Cocaine Use Disorders
|
Early Phase 1 | |
| Recruiting |
NCT05019430 -
Cocaine and Zolmitriptan
|
Early Phase 1 | |
| Recruiting |
NCT03344419 -
Glutamatergic Modulation to Facilitate the Behavioral Treatment of Cocaine Use Disorders
|
Phase 3 | |
| Recruiting |
NCT05507814 -
Temporal Window and Episodic Future Thinking in CUD
|
N/A | |
| Active, not recruiting |
NCT03799341 -
Neurocognitive Factors in Substance Use Treatment Response: The Ways of Rewarding Abstinence Project
|
N/A | |
| Completed |
NCT02785406 -
Role of the Orexin Receptor System in Stress, Sleep and Cocaine Use
|
Phase 2 | |
| Completed |
NCT02798627 -
Trial Of NS2359 For The Treatment of Cocaine Dependence
|
Phase 2 | |
| Completed |
NCT02444208 -
A Feasibility Trial for Inhibitory-Control Training to Reduce Cocaine Use
|
N/A | |
| Recruiting |
NCT05902819 -
Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories
|
N/A | |
| Recruiting |
NCT05833529 -
Innovative Cognitive and Behavioral Psychotherapy for Cocaine Use Disorder
|
N/A | |
| Recruiting |
NCT05521854 -
Contingency Management for Drug Use: Does Age Matter?
|
N/A |