Cocaine Use Disorder Clinical Trial
Official title:
Linking Nociceptive Opioid Peptide (NOP) Receptors With Relapse in Cocaine Use Disorders
Verified date | August 2019 |
Source | University of Pittsburgh |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The goal of this study is to compared [C-11]NOP-1A binding in recently abstinent cocaine use disorders and controls.
Status | Completed |
Enrollment | 49 |
Est. completion date | February 20, 2019 |
Est. primary completion date | February 20, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 50 Years |
Eligibility |
[A]Cocaine use disorders Inclusion criteria: 1. Males or Females 18-50 2. Fulfill DSM-5 Diagnosis for Cocaine use disorder 3. Medically Healthy Major exclusion criteria: 1. Pregnancy or lactation 2. Comorbid medical, psychiatric, drug use disorders (other than cocaine, tobacco use, and recreational marijuana/alcohol use) 3. Metal implants or paramagnetic objects contained within the body which may interfere with the MRI scan 4. Currently employed as radiation worker; or participation in radioactive drug research protocols within the previous year 5. Currently on any psychotropic medications that can influence nociceptin transmission in the brain (e.g., morphine, suboxone, SSRIs, etc.) [B] Healthy controls Inclusion criteria: 1. Males or Females 18-50 2. Absence of present or past psychiatric conditions (including alcohol or drug use disorders) 3. A negative urine drug screen 4. Medically Healthy Major exclusion criteria 1. Pregnancy or lactation 2. Medical, psychiatric or drug & alcohol use disorders 3. Metal implants or paramagnetic objects contained within the body which may interfere with the MRI scan 4. Currently employed as radiation worker; or participation in radioactive drug research protocols within the previous year 5. Currently on any psychotropic medications that can influence nociceptin transmission in the brain 6. Family history of a psychotic disorder, manic episode, drug use disorders in first-degree relatives. |
Country | Name | City | State |
---|---|---|---|
United States | University of Pittsburgh | Pittsburgh | Pennsylvania |
Lead Sponsor | Collaborator |
---|---|
University of Pittsburgh | National Institute on Drug Abuse (NIDA) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | [C-11]NOP-1A VT | VT-volume of distribution expressed relative to total plasma | Baseline |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03538548 -
Treatment Outcome in CBT for Cocaine Use
|
N/A | |
Recruiting |
NCT04994821 -
tDCS to Reduce Craving in Cocaine Addiction- Phase 2 Study
|
Phase 2 | |
Not yet recruiting |
NCT06050304 -
CRACK-TARGET 1: ÉTUDE DESCRIPTIVE DE LA SENSIBILISATION COMPORTEMENTALE OBSERVÉE et ATTENTES
|
||
Completed |
NCT02233647 -
Phendimetrazine and Cocaine
|
Early Phase 1 | |
Completed |
NCT02239913 -
Topiramate-Phentermine Combinations for Cocaine Dependence
|
Phase 1 | |
Not yet recruiting |
NCT05974202 -
rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder
|
Phase 2 | |
Recruiting |
NCT04927143 -
Encouraging Abstinence Behavior in a Drug Epidemic
|
Phase 2 | |
Completed |
NCT03224546 -
Cocaine Use Reduction and Health
|
N/A | |
Recruiting |
NCT03656653 -
Imagery-based Coping for Cocaine Use Disorder
|
N/A | |
Recruiting |
NCT05019430 -
Cocaine and Zolmitriptan
|
Early Phase 1 | |
Recruiting |
NCT03344419 -
Glutamatergic Modulation to Facilitate the Behavioral Treatment of Cocaine Use Disorders
|
Phase 3 | |
Recruiting |
NCT05507814 -
Temporal Window and Episodic Future Thinking in CUD
|
N/A | |
Active, not recruiting |
NCT03799341 -
Neurocognitive Factors in Substance Use Treatment Response: The Ways of Rewarding Abstinence Project
|
N/A | |
Completed |
NCT02798627 -
Trial Of NS2359 For The Treatment of Cocaine Dependence
|
Phase 2 | |
Completed |
NCT02785406 -
Role of the Orexin Receptor System in Stress, Sleep and Cocaine Use
|
Phase 2 | |
Completed |
NCT02444208 -
A Feasibility Trial for Inhibitory-Control Training to Reduce Cocaine Use
|
N/A | |
Recruiting |
NCT05902819 -
Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories
|
N/A | |
Recruiting |
NCT05833529 -
Innovative Cognitive and Behavioral Psychotherapy for Cocaine Use Disorder
|
N/A | |
Recruiting |
NCT05521854 -
Contingency Management for Drug Use: Does Age Matter?
|
N/A | |
Completed |
NCT05557149 -
Virtual Reality Exposure and Respiratory Relaxation-Based Coping With Cocaine Craving in Cocaine Users
|
N/A |