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Cluster Headache clinical trials

View clinical trials related to Cluster Headache.

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NCT ID: NCT04949204 Completed - Migraine Clinical Trials

Context-awareness, Physiological Monitoring, and Machine Learning in Migraine and Cluster Headache

COPIMAC
Start date: July 1, 2020
Phase:
Study type: Observational

This is an observational, longitudinal cohort pilot study measuring physiological signals through wearable sensors combined with machine learning algorithms to detect behaviour, stress and headaches in patients with migraine and cluster headache.

NCT ID: NCT04939922 Recruiting - Fibromyalgia Clinical Trials

China Headache Registry Study

CHRS
Start date: June 12, 2017
Phase:
Study type: Observational [Patient Registry]

In the Chinese Headache and Vertigo Registration Study, patients aged 4-99 years with headache (primary headache and secondary headache such as migraine and tension type headache), vertigo (vertigo diseases such as vestibular migraine) and chronic pain (fibromyalgia and other diseases) were collected. The biomarkers, imaging features, right-to-left shunt of the heart (lung), genetic characteristics, treatment, and outcome (in relation to other diseases) of headache-related diseases were studied, and long-term follow-up was planned.

NCT ID: NCT04930887 Recruiting - Migraine Clinical Trials

Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial Pain

Start date: February 1, 2023
Phase: Phase 2
Study type: Interventional

Exparel has a proven efficacy in providing pain relief for up to 72 hours with a single-dose administration at surgical sites. The study aims to evaluate the effectiveness of endoscopically-guided injection of Exparel (Bupivacaine) for the treatment of craniofacial pain. This study would be conducted in a prospective, randomized, double-blinded, placebo- controlled, and cross-over fashion. We aim to investigate whether the administration of Exparel (Bupivacaine) to the lateral nasal wall may positively impact craniofacial pain and functional outcomes, in patients who experience relief with the topical application of Lidocaine (routinely given prior to almost all ENT endoscopy).

NCT ID: NCT04845451 Completed - Cluster Headache Clinical Trials

The Presence and Role of Zygomatic-temporal Neuroma Triggering Cluster Headache

Start date: June 9, 2021
Phase:
Study type: Observational

Role of a neuroma of zygomatic-temporal in triggering of a cluster headache. Exploratory diagnosis, resection, and pathological examination of tumor anticipated .

NCT ID: NCT04814381 Recruiting - Clinical trials for Refractory Chronic Cluster Headache

Ketamine + Magnesium for Chronic Cluster Headache (KETALGIA)

KETALGIA
Start date: September 15, 2021
Phase: Phase 4
Study type: Interventional

Chronic cluster headache (CCH) is a rare primary headache disorder, defined by episodic attacks that occur for more than one year with no remission period or with remission periods lasting < 3 months (ICHD-3 criteria). In certain cases, CCH patients become drug-resistant and continue to suffer almost daily attacks. Ketamine appears to be effective in a variety of chronic pain conditions, such as refractory headache, and can show an enhanced analgesic effect when combined with magnesium. A single infusion of ketamine-magnesium combination has been described to reduce attacks in 17 patients with rCCH. The main outcome was a comparison of the number of daily attacks two weeks prior to the infusion and one week after (days 7-8). The number of daily attacks decreased from 4.3±2.4 before treatment to 1.3±1.0 after treatment (p<0.001). 13/17 had at least 50% response. Thus, the goal of this placebo-controlled study is to try to confirm these findings.

NCT ID: NCT04688775 Completed - Clinical trials for Cluster Headache, Episodic

Eptinezumab in Participants With Episodic Cluster Headache

ALLEVIATE
Start date: December 23, 2020
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy of eptinezumab in participants with episodic Cluster Headache (eCH)

NCT ID: NCT04570475 Terminated - Cluster Headache Clinical Trials

High Dose Vitamin D Plus Multivitamin in the Prevention of Cluster Headache

Start date: September 15, 2021
Phase: Phase 3
Study type: Interventional

This study intends to investigate the use of high-dose Vitamin D3 plus a multivitamin in the prevention of cluster headache attacks. Participants can be enrolled anywhere in the United States that has access to one of our participating labs (for blood work - anticipated to be available in most of the USA). The study may include: - Screening: Participants may be interviewed, examined, fill out surveys, and get blood testing - Week 1: baseline period (no added medications - to establish a baseline) - Weeks 2-4: double-blinded experimental period - participants receive either 1) high-dose Vitamin D3 + multivitamin, or 2) placebo + multivitamin. Participants also fill out a survey and have blood testing. - Weeks 5-7: open-label period - ALL participants receive high-dose Vitamin D3 + multivitamin. Participants also fill out a survey and may have blood testing. Specifically, our primary outcome is the change from baseline to experimental weeks 1-3 in the frequency of cluster headache attacks between placebo and high-dose vitamin D. Specific primary and secondary outcomes are listed below.

NCT ID: NCT04467398 Recruiting - Clinical trials for Trigeminal Neuralgia

Incidence of Intravascular (IV) Injection During Trigeminal Nerve Blocks

Start date: July 20, 2020
Phase:
Study type: Observational [Patient Registry]

The purpose of this study is to investigate the incidence of intravascular injection during trigeminal nerve blocks.

NCT ID: NCT04439409 Terminated - Cluster Headache Clinical Trials

Variability of the Autonomic Nervous System (ANS) During Cluster Headache (CH).

AVASNA
Start date: August 19, 2020
Phase:
Study type: Observational

Cluster Headache (CH) is associated with ipsilateral vegetative signs, related to parasympathetic system hyperactivity and/or signs of sympathetic hypoactivity. The precise mechanism of Cluster Headache (CH) is still unknown. The question is whether these dysautonomic disorders are simply secondary to the Cluster Headache (CH) process or whether they are the triggering factor.

NCT ID: NCT04409977 Recruiting - Cluster Headache Clinical Trials

Circadian Changes of the Hypothalamic Activity in Patients Suffering From Cluster Headache

Start date: June 26, 2019
Phase:
Study type: Observational

Cluster headache attacks do not occur randomly throughout the day, but have a clear circadian rhythmicity. The aim of this study is to investigate circadian changes of the brain, the autonomic nervous system and pain processing systems.