| Eligibility |
- INCLUSION CRITERIA:
- Patients must have histologically proven metastatic clear cell renal carcinoma with
greater than or equal to 5% expression of programmed death-ligand 1 (PD-L1) on the
tumor cells confirmed by immunohistochemistry (IHC) in the national Cancer Institute
(NCI) Lab of Pathology. Archival tumor sample may be used but if archival tissue is
not available or is not adequate, tissue biopsy will be required.
- Patients must have failed or relapsed and have progressive disease after at least 2
prior therapies that include multityrosine kinase inhibitor (mTKI) like axitinib or
sunitinib and an anti-Programmed cell death protein 1 (PD1) or PD-L1 (ICI) therapy
like nivolumab which could have been administered in combination with an anti-cluster
of differentiation 152 (CTLA4) agent like ipilimumab. Patients who received an immune
checkpoint inhibitor (ICI) in combination with a mTKI would be eligible for the trial
if they received another appropriate treatment. Adjuvant or neoadjuvant with either
type of agent would not fulfill this requirement only treatment for metastatic disease
will be considered to satisfy this criterion.
- Disease must be measurable with at least one measurable lesion by the Response
Evaluation Criteria in Solid Tumors (Recist) v1.1 criteria that is different from the
lesion biopsied.
- Age >=18 years
NOTE: Because no dosing or adverse event data are currently available on the use of
recombinant human Interleukin-15 (rhIL-15) in combination with avelumab in patients <18
years of age, children are excluded from this study, but may be eligible for future
pediatric trials
- Eastern Cooperative Oncology Group (ECOG) performance status <= 1 (Karnofsky >=80%)
- Adequate organ and marrow function as defined below:
- absolute neutrophil count greater than or equal to 1,500/mcL
- absolute lymphocyte count greater than or equal to 500/mcL
- Hemoglobin greater than or equal to 10 g/dL
- Platelets greater than or equal to 100,000/mcL
- total bilirubin less than or equal to 1.5 X institutional upper limit of normal
(ULN)
- Aspartate aminotransferase (AST) serum glutamic-oxaloacetic transaminase
(SGOT)/Alanine aminotransferase (ALT) Serum glutamic pyruvic transaminase (SGPT)
less than or equal to 2.5 X institutional ULN
- Serum creatinine less than or equal to 1.5 X institutional ULN
OR
- Creatinine clearance greater than or equal to 50 mL/min/1.73 m^2 for patients with
creatinine levels >1.5 institutional ULN
- Negative serum or urine pregnancy test at screening for women of childbearing
potential (WOCBP).
NOTE: WOCBP is defined as any female who has experienced menarche and who has not undergone
successful surgical sterilization or who is not postmenopausal. WOCBP must have a negative
pregnancy test (human chorionic gonadotropin (HCG) blood or urine) during screening.
- Women of child-bearing potential and men must agree to use adequate contraception
(hormonal or barrier method of birth control; abstinence) prior to study entry, for
the duration of study participation, and 1 month after completion of rhIL-15 and
avelumab administration. Should a woman become pregnant or suspect she is pregnant
while she or her partner is participating in this study, she should inform her
treating physician immediately.
- Ability of subject to understand and the willingness to sign a written informed
consent document.
EXCLUSION CRITERIA:
- Chemotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C).
- Persisting toxicity related to prior therapy of grade > 1, with the exception of the
following: alopecia, sensory neuropathy grade <= 2, or other grade <= 2 not
constituting a safety risk based on investigator's judgement.
- Patients who are receiving any other investigational agents
- Current use of immunosuppressive medication, EXCEPT for the following:
- Intranasal, inhaled, topical steroids, or local steroid injection (e.g.,
intra-articular injection)
- Systemic corticosteroids at physiologic doses <= 10 mg/day of prednisone or
equivalent; or,
- Steroids as premedication for hypersensitivity reactions (e.g., computed
tomography (CT) scan premedication).
- Patients with known brain metastases should be excluded from this clinical trial
because of their poor prognosis and because they often develop progressive neurologic
dysfunction that would confound the evaluation of neurologic and other adverse events.
- Patients with previous malignant disease other than the target malignancy within the
last 5 years with the exception of basal or squamous cell carcinoma of the skin or
cervical carcinoma in situ.
- Patients with history of any organ transplantation
- Vaccination within 4 weeks of the first dose of avelumab. Vaccination with a live
vaccine while on trial is prohibited.
NOTE: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and
are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated
vaccines, and are not allowed.
- Patients with history of allergic reactions attributed to compounds of similar
chemical or biologic composition to rhIL-15 or avelumab.
- Patients with uncontrolled intercurrent illness including, but not limited to, ongoing
or active infection requiring systemic therapy, or psychiatric illness/social
situations that would limit compliance with study requirements.
- Inability or refusal to practice effective contraception during therapy or the
presence of pregnancy or active breastfeeding. Based on its mechanism of action,
avelumab can cause fetal harm when administered to a pregnant woman. Animal studies
have demonstrated that inhibition of the PD-1/PD-L1 pathway can lead to increased risk
of immune-mediated rejection of the developing fetus resulting in fetal death. These
potential risks may also apply to other agents used in this study.
- Patients with active bacterial infections, documented human immunodeficiency virus
(HIV) infection or positive screening serology, polymerase chain reaction (PCR)
evidence for active or chronic hepatitis B or hepatitis C, or positive screening
hepatitis B virus (HBV)/hepatitis C virus (HCV) serology without documentation of
successful curative treatment
- Patients with active or history of any autoimmune disease, including asthma requiring
chronic inhaled or oral corticosteroids, or with history of asthma requiring
mechanical ventilation; patients with a history of mild asthma that are on or can be
switched to non-corticosteroid bronchodilator regimens are eligible
- Cardiovascular disease: Clinically significant (i.e., active) cardiovascular disease:
cerebral vascular accident/stroke (< 6 months prior to enrollment), myocardial
infarction (< 6 months prior to enrollment), unstable angina, congestive heart failure
(greater than or equal to New York Heart Association Classification Class II), or
serious cardiac arrhythmia requiring medication
- Other severe acute or chronic medical conditions including immune colitis,
inflammatory bowel disease, immune pneumonitis, pulmonary fibrosis or psychiatric
conditions including recent (within the past year) or active suicidal ideation or
behavior; or laboratory abnormalities that may increase the risk associated with study
participation or study treatment administration or may interfere with the
interpretation of study results and, in the judgment of the investigator, would make
the patient inappropriate for entry into this study.
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