Clinical Trials Logo

Clinical Trial Summary

Claustrophobia is an irrational fear of restriction and suffocation. It is a specific phobia, according to DSM 5. Claustrophobic patients may fear that restriction of their limbs will hinder their ability to move quickly towards safety. MRI may trigger claustrophobia, because this diagnostic procedure involves a patient laying in a narrow tube. Premedication before MRI scan may occasionally reduce claustrophobia. Prospective observational crossover study of claustrophobic patients who are undergoing MRI scan. At alternate MRI scan sessions, each patient receives rotational premedication using Lorazepam 1mg; or Clonidine tablet 0.2mg; or combined Clonidine 0.2mg + Lorazepam 1mg. Patient will use Claustrophobia Questionnaire, a validated tool, to collect data on the days before and after each MRI scan. CLQ is a patient-administered tool used to assess claustrophobia. In addition, patient will use General Anxiety Disorder Questionnaire, a validated tool, to collect data on the days before and after each MRI scan. GAD-7 is a patient-administered tool that is used to assess anxiety.


Clinical Trial Description

Claustrophobia is an irrational fear of constraint, restriction, immobility, smothering and suffocation. Claustrophobia is a specific phobia, according to the Diagnostic and Statistical Manual 5 (DSM 5). The disorder affects 5% of the general population. Claustrophobic patients may fear that the restriction of their limbs will hinder their ability to move quickly towards perceived safety. Magnetic resonance imaging (MRI) may trigger claustrophobia, because this diagnostic procedure involves a patient staying immobile in a narrow and noisy tube. Anxiolytic premedication before MRI scan, using Lorazepam, may occasionally help to reduce claustrophobia. This is a prospective observational crossover study of claustrophobic adult patients who are undergoing MRI scan as part of chronic pain management. At alternate MRI scan sessions, each patient receives rotational premedication using Lorazepam 1mg; or Clonidine tablet 0.2mg; or combined Clonidine 0.2mg + Lorazepam 1mg. The patient will use the Claustrophobia Questionnaire (CLQ), a special validated tool, to collect data on the days before and after each MRI scan. The CLQ is a patient-administered tool that is used to record the severity and presence of claustrophobia symptoms, on a measurement range of 0 to 104. A change in the CLQ scores by 12-points is considered significant. In addition, the patient will use the General Anxiety Disorder Questionnaire (GAD-7), a special validated tool, to collect data on the days before and after each MRI scan. The GAD-7 is a patient-administered tool that is used to record the severity and presence of anxiety symptoms, on a measurement range of 0 to 21. A change in the GAD-7 scores by 3-points is considered significant. Data analyzed with IBM® SPSS® Statistics 25 (IBM Corp, Armonk, NY); using Student's t-test, ANOVA, Pearson Chi-square test, and regression analysis. P-value <0.05 is considered significant. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05876117
Study type Observational
Source Salem Anaesthesia Pain Clinic
Contact Olu Bamgbade, MD,FRCPC
Phone 17786286600
Email salem.painclinic@gmail.com
Status Recruiting
Phase
Start date July 4, 2020
Completion date December 31, 2024

See also
  Status Clinical Trial Phase
Completed NCT04520100 - Pilot Trial of Hypnosis and Enhanced Communication In Patients Undergoing MRI N/A
Recruiting NCT04536116 - Virtual Reality as Anxiety Management Tool for Preparing Children for MR Exam N/A
Not yet recruiting NCT04754958 - Virtual Reality to Alleviate Claustrophobia During MRI N/A
Not yet recruiting NCT06257121 - Comparing Radiotherapy Immobilization Systems for Anxious HNC Patients N/A
Completed NCT00715806 - Claustrophobia and Magnetic Resonance Imaging N/A
Recruiting NCT03384849 - Evaluation of an MRI-compatible Vital Signs Sensor System N/A
Completed NCT04663672 - Efficacy of Targeted Memory Reactivation for Enhancing Exposure Therapy N/A
Completed NCT01367067 - Prediction of Claustrophobia During MR Imaging
Completed NCT05304143 - Efficacy of Immersive Entertainement Glasses in Magnetic Resonance Imaging (MRI) N/A
Completed NCT01563198 - Reduction of Claustrophobia and Patient Motion After Training of MRI Personnel in Comfort TalkTM N/A
Completed NCT02926352 - Effects of Low-Level Laser Stimulation With and Without Fear Extinction Training Phase 1/Phase 2
Completed NCT02427737 - Comfort Talk and Economic Outcomes in MRI N/A