Cirrhosis With Septic Shock Clinical Trial
Official title:
A Prospective Open Label Randomized Non Inferiority Trial to Compare the Efficacy and Safety of Monotherapy With Noradrenaline and Terlipressin in Patients of Cirrhosis With Septic Shock Admitted to Intensive Care Unit.
The Patient evaluated in Emergency room since admission and detailed history and clinical
examination done .The in hospital cases where sepsis is the culprit and shifted to Intensive
Care Unit (ICU) in view of septic shock were included since onset of shock.
Initial fluid resuscitation done and if the patient were no fluid responsive they were
randomized into arms noradrenaline or terlipressin and the dose escalated to achieve the
primary objectives. At the same time the strict vitals monitoring and standard medical
therapy for sepsis including antibiotics and other supportive therapy continued. The
patients were followed up till discharge, death or up to 28days after enrollment into the
protocol (whichever the longest). The detail methodology has been explained in column 14
later.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02468063 -
To Assess the Efficacy of Early Introduction of a Combination of Low Dose Vasopressin Analogue in Addition to Noradrenaline as a Vasopressor in Patients of Cirrhosis With Septic Shock
|
N/A | |
| Completed |
NCT02462902 -
Comparison And Outcomes Of Fluid Resucitation With 0.9% Normal Saline And 5% Albumin In Cirrhosis Patients With Sepsis Induced Hypotension
|
N/A |