Cirrhosis, Liver Clinical Trial
Official title:
Clinical Validation of the Use of Global Coagulation Tests Like Thromboelastography and Sonoclot in Liver Disease - A Prospective Observational Study.
Background: Patients with cirrhosis and acute-on-chronic liver failure (ACLF) may have
bleeding complications which can lead to increased mortality. Standard coagulation tests
(SCTs) like prothrombin time, platelet count and activated partial thromboplastin do not
accurately depict in vivo coagulation profile. Point-of-care viscoelastic coagulation testing
devices like thrombo-elastography (TEG) and Sonoclot may be better for guiding patient
management.
Methods: This prospective observational study compared and validated the point of care (POC)
tests and SCTs in 70, 72 and 25 persons with ACLF, decompensated cirrhosis and healthy
controls respectively.
n/a
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