Circulatory Failure Clinical Trial
Official title:
Can Capillary Refill Time Variation Induced by Passive Leg Raising Predict Capillary Refill Time Variation After a Fluid Load in Patients With Circulatory Failure.
Fluid responsiveness in a context of circulatory failure can be assessed by different way.
Microcirculatory evaluation to assess fluid responsiveness could be interesting, but the
available device are expensive and the analysis are delayed. Capillary refill time (CRT) is
hampered by its variability. The investigators have developed a method to standardize the
pressure, the length of compression and a computerized analysis to calculate the capillary
refill time. This method enables accurate measure of CRT.
The investigators will study if CRT variation induced by a passive leg raising (PLR) can
predict CRT after a 500 ml Fluid Load.
About thirty patients in circulatory failure with a continuous cardiac output monitoring for
whom, the attending physician has decided a fluid load, will be included. hemodynamic
parameters (arterial pressure, venous pressure, cardiac output), metabolic parameters
(arterial and venous blood gas and lactate), microcirculatory parameters (assessed by
sublingual video-microscopy) and capillary refill time measured on the thorax and on the
gingival area will be recorded. Data collection will be made before and after a passive leg
raising and after a 500 ml fluid load of crystalloids.
Patients will be aposteriori sorted in two groups: responders and non responders, defined by
the reduction of CRT after the fluid load. The diagnosis ability of the CRT variation after
PLR to predict in which group each patient is classified will be investigate and receiver
operative characteristic curve will be built. These results will be compared to the
metabolic response, the macrocirculatory response, and the microcirculatory response.
n/a
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