Cicatrix, Hypertrophic Clinical Trial
Official title:
To Study Gene Expression of Postburn Hypertrophic Scar
Aim: To compare the gene expression of postburn hypertrophic scar with normal skin.
Background: Postburn hypertrophic scar (HS) remains a challenging problem. Although varied
clinical therapeutic methods have been used, none of them has been widely accepted as a
standard care. As hypertrophic scar is hereditary, gene therapy can be a potential tool for
scar treatment. To investigate the correlation between the clinical presentation of the
hypertrophic scar and its gene expression, we propose an analysis of gene expression in the
hypertrophic scar using DNA microarray and Real-Time Quantitative PCR. The study result may
form the base of clinical treatment.
Methods and Materials: Thirty scar patients requiring surgical treatment in NTUH burn center
will be enrolled into the study. Inclusion criteria: (1) Age between 20 and 80 (2) Patients
with postburn hypertrophic scar require surgical treatment.
1. Hypertrophic scar and normal skin collection: Under Clinical Trial Informed Consent of
Research Ethic Committee, scar and normal skin specimen of 1x1cm2 each will be
collected and transported to tissue bank with a vacuum low temperature container. The
specimen will be kept in a -80℃ refrigerator.
2. RNA extraction from skin tissue: The RNA extraction will be performed using kit
available in the market. Spectrophotometer and gel electrophoresis will be used to
measure the purity and concentration of RNA.
3. Gene expression analysis: DNA microarray and Real-Time Quantitative PCR will be used to
analyze RNA expression of hypertrophic scar and normal skin.
Statistics: Student's t-test will be used to compare statistically gene expression between
hypertrophic scar and normal skin. P < 0.05 will be considered as statistical significance.
;
Observational Model: Case Control, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT03628495 -
Effectiveness of a Combined Pressure and Silicone Intervention for Hypertrophic Scar Treatment
|
N/A | |
| Completed |
NCT02707627 -
Laser Therapy for Pediatric Burn Scars
|
||
| Completed |
NCT03366194 -
The Clinical Efficacy And Safety Of SkinStylus Microneedling System
|
N/A | |
| Terminated |
NCT04236167 -
Fractional CO2 Laser Treatment of Hypertrophic Scars
|
N/A | |
| Completed |
NCT03469830 -
The Development and Application of "Scar-care" Padding on Management of Hypertrophic Scar
|
N/A | |
| Completed |
NCT03569267 -
A Study to Evaluate Safety and PK Profiles of OLX10010 in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT02340325 -
FS2 Safety and Tolerability Study in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT00754247 -
A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars
|
Phase 4 | |
| Completed |
NCT01040104 -
Prospective Clinical Trials on Skin Wound Healing in Young and Aged Individuals
|
N/A | |
| Recruiting |
NCT06122090 -
Treatment of Hypopigmented Scars With Bimatoprost
|
Phase 2 | |
| Completed |
NCT01994616 -
Prospective Evaluation of the Use of Intralesional Cryotherapy for Treatment of Keloid and Hypertrophic Scars
|
N/A | |
| Recruiting |
NCT00565552 -
Influence of a Silicone Gel (Dermatix®) on Thoracic Scar Formation After Harvesting of Autologous Rib Cartilage
|
N/A | |
| Completed |
NCT04558944 -
The Effect of Extracorporeal Shock Wave Therapy in the Treatment of Post Burn Scars
|
N/A | |
| Completed |
NCT01789346 -
Pilot Study of a Novel 532nm KTP Laser for the Treatment of Fresh Surgical Scars
|
N/A |