Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00598611
Other study ID # P04805-V2.0
Secondary ID EudraCT number:
Status Completed
Phase Phase 3
First received January 10, 2008
Last updated May 30, 2012
Start date September 2007
Est. completion date August 2009

Study information

Verified date May 2012
Source Charite University, Berlin, Germany
Contact n/a
Is FDA regulated No
Health authority Germany: Federal Institute for Drugs and Medical Devices
Study type Interventional

Clinical Trial Summary

The purpose of this study is to compare urticaria lesions (size, kinetics) by thermography, volumetry and digital time lapse photography in CU patients treated with desloratadine 5 mg or desloratadine 20 mg. Hypothesis: Updosing of desloratadine (20mg) is more efficient in the treatment of urticarial lesions as compared to standard dosing (5 mg desloratadine).


Recruitment information / eligibility

Status Completed
Enrollment 29
Est. completion date August 2009
Est. primary completion date August 2009
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 75 Years
Eligibility Inclusion Criteria:

1. Outpatients with moderate to severe CU for more than 6 weeks. Urticaria symptoms must comprise wheal and itch.

2. Patients must exhibit spontaneous urticaria lesions in the randomization visit.

3. History of beneficial effects of antihistaminic treatment.

4. Age between 18 and 60 years.

5. Female patients must be using adequate contraceptive precautions (highly effective method), or they must be postmenopausal, surgically sterilised, or hysterectomised (for details please see protocol).

6. Female patients must be using adequate contraceptive precautions (contraceptive pill, depot, double barrier methods), or they must be postmenopausal, surgically sterilised, or hysterectomised.

7. Voluntarily signed written informed consent.

Exclusion Criteria:

1. The presence of permanent severe diseases, especially those affecting the immune system, except CU.

2. The presence of permanent gastrointestinal condition which may influence the oral therapy (chronic diarrhea diseases, congenital malformations or surgical mutilations of the gastrointestinal tract).

3. History or presence of epilepsy, significant neurological disorders, cerebrovascular attacks or ischemia.

4. History or presence of myocardial infarction or cardiac arrhythmia which requires drug therapy.

5. Evidence of severe renal dysfunction

6. Evidence of significant hepatic disease (liver enzymes twice the upper reference value).

7. The presence of galactose intolerance, lapp lactase deficiency or glucose galactose malabsorption.

8. History of adverse reactions including hypersensitivity to DL and Loratadine.

9. Intake of medicaments that could cause QT changes (drugs listed on www.qtdrugs.org).

10. Presence of active cancer which requires chemotherapy or radiation therapy.

11. Presence of acute urticaria / angioedema including laryngeal edema

12. History or presence of alcohol abuse or drug addiction.

13. Participation in any clinical trial within 4 weeks prior to enrolment.

14. Intake of oral corticosteroids or other immunosuppressive therapy within 14 days prior to the beginning of the study.

15. Use of depot corticosteroids or chronic systemic corticosteroids within 21 days before beginning of the study.

16. Pregnancy or breast-feeding.

17. Existing or planned placement in an institution after ruling according to ยง 40 passage 1 number 4 AMG (Arzneimittelgesetz).

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment


Related Conditions & MeSH terms


Intervention

Drug:
desloratadine
singel dose, oral, 20 mg
desloratadine
single dose, oral, 5 mg

Locations

Country Name City State
Germany Allergie-Centrum-Charite Berlin

Sponsors (2)

Lead Sponsor Collaborator
Charite University, Berlin, Germany Essex Pharma GmbH

Country where clinical trial is conducted

Germany, 

Outcome

Type Measure Description Time frame Safety issue
Primary Reduction in size of existing spontaneous urticaria lesions (wheal and flare) as assessed by thermography. 5 hours No
Secondary Reduction in size of existing spontaneous urticaria lesions (wheal and flare) as assessed by volumetry and digital time lapse photography. 5 hours No
See also
  Status Clinical Trial Phase
Completed NCT02435238 - AWARE - Chronic Urticaria N/A
Not yet recruiting NCT05513079 - Positive Psychotherapy-Based Counseling (PPT) N/A
Terminated NCT02047136 - Dietary Treatment for Chronic Urticaria N/A
Completed NCT01803763 - Prospective Double-blind Placebo-controlled Study of the Effect of Xolair (Omalizumab) in Chronic Urticaria Patients Phase 2/Phase 3
Terminated NCT01170949 - Efficacy and Safety of Miltefosine in Antihistamine Resistant Chronic Urticaria Phase 2
Completed NCT01610128 - Development of an Urticaria Control Test N/A
Completed NCT02285023 - The Validity, Reliability and Interpretability of Thai-version of Chronic Urticaria Quality of Life Questionnaire
Completed NCT02285049 - Cross-Cultural of the Validity, Reliability and Interpretability of Thai-version of Urticaria Control Test N/A
Completed NCT01715740 - Study of the Effects of Chinese Herbal Medicine on Chronic Urticaria Phase 3
Completed NCT01960283 - Methotrexate in the Treatment of Chronic Idiopathic Urticaria Phase 3
Completed NCT00481676 - Efficacy and Safety of Omalizumab in Adults (18-70 Years) With Moderate to Severe Chronic Urticaria Phase 2
Completed NCT01713725 - Efficacy and Safety Study of Omalizumab (Xolair®) to Treat Chronic Urticaria Phase 2
Completed NCT01250652 - Levocetirizine Plus Bed-Time Hydroxyzine in the Management of Corticodependent Chronic Urticaria Versus Levocetirizine Alone in High Doses Phase 4
Completed NCT01111136 - Stress Intervention for Chronic Urticaria N/A
Recruiting NCT01425593 - T Cell Function in Chronic Idiopathic Urticaria N/A
Completed NCT00619801 - Safety Study of Levocetirizine Dihydrochloride Oral Liquid Formulation in Children Aged 1 to Less Than 6 Years Suffering From Allergic Rhinitis or Chronic Urticaria of Unknown Origin Phase 3
Completed NCT00737451 - Association of Thyroid Autoimmunity and Chronic Urticaria N/A
Completed NCT00628108 - Safety Study of Levocetirizine Dihydrochloride Oral Liquid Formulation in Children Aged 6 Months to 11 Months Phase 3
Completed NCT01284426 - Natural History of Chronic Urticaria N/A
Withdrawn NCT01073852 - Hydroxychloroquine Efficacy in Chronic Urticaria N/A

External Links