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Chronic Subdural Hematoma clinical trials

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NCT ID: NCT06134206 Completed - Clinical trials for Chronic Subdural Hematoma

Burr Hole Ultrasound Study

Start date: May 1, 2022
Phase: N/A
Study type: Interventional

Chronic subdural hematoma (CSDH) is commonly managed through burr hole evacuation. This study evaluates the feasibility of trans burr hole sonography as an alternative postoperative imaging modality. A pilot study on 20 patients who underwent burr hole surgery for CSDH was therefore planned. Postoperative imaging included both CT and sonographic examinations through the burr hole. We assessed the ability to measure residual subdural fluid thickness sonographically compared to CT.

NCT ID: NCT04270955 Completed - Clinical trials for Chronic Subdural Hematoma

Dartmouth Middle Meningeal Embolization Trial (DaMMET)

DAMMET
Start date: March 11, 2020
Phase: N/A
Study type: Interventional

Chronic subdural hematomas (cSDH) are one form of bleeding in the head. They are one of the most common diseases encountered by neurosurgeons across the country. The cSDH can push on the brain and produce symptoms that include seizures, weakness, loss of sensation, and confusion. Many of these cSDH produce repetitive bleeding. Treatment has largely consisted of surgical drainage of hematoma (also known as a blood clot) through either a small hole in the skull or open surgery. However, it is common for the cSDH to reappear despite these procedures. A recent study has shown a treatment failure rate of 27% and a need for additional surgery at 19%. A new approach to treatment of cSDH blocks the blood supply to the tissue that produces the repeated bleeding. Catheters are used to gain access to the middle meningeal artery (MMA), an artery that supplies the coverings of the brain. The artery is blocked using small particles or glue in a process called embolization. A recent pilot study of 72 patients who underwent MMA embolization showed a much lower rate of repeated bleeding. Based on these results, it is thought that this procedure holds promise in reducing the number of cSDH that require one or more operations. The goal of this study is to systematically examine if blocking the blood supply to the tissue responsible for repeated bleeding helps the cSDH resolve and improves patient outcomes.

NCT ID: NCT04203550 Completed - Clinical trials for Chronic Subdural Hematoma

The Finnish Study of Intraoperative Irrigation Versus Drain Alone After Evacuation of Chronic Subdural Hematoma (FINISH)

FINISH
Start date: January 1, 2020
Phase: N/A
Study type: Interventional

FINISH-trial is a prospective, randomized, controlled, parallel group non-inferiority trial comparing single burr-hole evacuation of chronic subdural hematoma (CSDH) with intraoperative irrigation (IR) and evacuation of CSDH without irrigation (N-IR).

NCT ID: NCT03447327 Completed - Clinical trials for Chronic Subdural Hematoma

Outcome of Single Burr Hole Under Local Anaesthesia in the Management of Chronic Subdural Hematoma

Start date: March 5, 2014
Phase: N/A
Study type: Interventional

Aim of the work: Is to evaluate the prognosis of single burr hole under local anesthesia in management of CSDH according to clinical picture, risk factors, and age.

NCT ID: NCT03307395 Completed - Clinical trials for Chronic Subdural Hematoma

Middle Meningeal Artery Embolization for Treatment of Chronic Subdural Hematoma

Start date: October 31, 2017
Phase: N/A
Study type: Interventional

Middle meningeal artery (MMA) embolization via a minimally invasive endovascular approach has been attempted with the goal of eliminating the arterial supply to the vascularized membrane. The investigators have recently presented the first known case series of MMA embolization as upfront treatment for cSDH in lieu of surgical evacuation (publication pending). Five patients underwent successful embolization of the MMA with subsequent reduction in size or complete resolution of cSDH with no peri-procedural complications. The purpose of this study will be to evaluate the safety and efficacy of MMA embolization compared to traditional surgical management for symptomatic, chronic, and medically refractory SDH. MMA embolization is an established procedure used routinely for treatment of tumors or vascular malformations; this study investigates the use of an established procedure for a new disease. The investigators hypothesize that MMA embolization will afford a particularly fragile patient population an alternative to invasive and morbid neurosurgical intervention.

NCT ID: NCT03120182 Completed - Clinical trials for Chronic Subdural Hematoma

Chronic Subdural Hematoma and Aspirin

SECA
Start date: February 19, 2018
Phase: N/A
Study type: Interventional

The aim of this randomized, blinded, placebo controlled clinical study is to compare the peri- and postoperative bleeding and cardiovascular complication rates of patients undergoing burr-hole trepanation for chronic subdural hematoma with and without discontinuation of low-dose aspirin

NCT ID: NCT02757235 Completed - Clinical trials for Chronic Subdural Hematoma

The Swedish Study of Irrigation Fluid Temperature in the Evacuation of Chronic Subdural Hematoma

SIC!
Start date: March 2016
Phase: N/A
Study type: Interventional

The study will be a multicenter randomised controlled trial of the use of irrigation fluid of body temperature versus irrigation fluid of room temperature during burr hole evacuation of chronic subdural hematoma.

NCT ID: NCT02655445 Completed - Clinical trials for Chronic Subdural Hematoma

Randomized Controlled Trial Investigating Optimal Treatment for Chronic Subdural Hematoma

Start date: January 2012
Phase: N/A
Study type: Interventional

Setup of comparative trial The goal of this study is to determine whether one surgical treatment for chronic subdural hematoma is better than the other. Patients with a clear indication for drainage of subdural hematoma (as stated under "Surgical options") will be randomized into three groups. One group will receive twist drill craniostomy followed by drainage during 48 hours. One group will undergo burr hole drainage (single if possible, double if necessary) with irrigation and drainage during 48 hours postoperatively. One group will undergo a minicraniotomy with trephine or craniotome, with wide opening of all visible membranes, rigorous irrigation and placement of Jackson-Pratt drain, followed by closed system draining during 48 hours. Postoperative results and complications will be compared between the three groups.

NCT ID: NCT02282228 Completed - Healthy Volunteers Clinical Trials

Detecting Chronic Subdural Hematoma With Microwave Technology

Start date: November 2014
Phase: N/A
Study type: Interventional

An open study evaluating the sensitivity and specificity of a microwave-based device, Medfield Strokefinder MD100, to detect chronic subdural hematoma, by comparing measurements on patients recruited for surgery of chronic subdural hematoma to an age- and gender-matched group of healthy volunteers.

NCT ID: NCT02024373 Completed - Clinical trials for Chronic Subdural Hematoma

Effect and Safety Study of Atorvastatin to Treat Chronic Subdural Hematoma

Start date: December 2013
Phase: Phase 2
Study type: Interventional

To evaluate the clinic effects and security of oral administration of Atorvastatin on chronic subdural hematoma (CSDH).