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Clinical Trial Summary

This study aims to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) following a single subcutaneous injection of YH35324 in subjects with various allergic diseases.


Clinical Trial Description

This drug(YH35324) is currently under development as a novel therapeutic agent for various IgE-mediated allergic diseases. Since YH35324 exhibits high binding affinity to human IgE, it prevents serum IgE from binding to receptors on mast cells and basophils, thereby inhibiting histamine release via degranulation following allergen exposures. In addition, YH35324 suppresses autoantibody-dependent effector cell activation by blocking anti-FcεRIα autoantibodies. This study aims to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) following a single subcutaneous injection of YH35324 in subjects with various allergic diseases. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05960708
Study type Interventional
Source Yuhan Corporation
Contact JungWook Ahn
Phone +82 2-828-0734
Email ajw8299@yuhan.co.kr
Status Recruiting
Phase Phase 1
Start date August 23, 2023
Completion date August 26, 2024

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