Chronic Respiratory Failure Clinical Trial
Official title:
Adaptation to Nocturnal Noninvasive Ventilation in Patients With Chronic Respiratory Failure
BACKGROUND: Adaptation to noninvasive ventilation (NIV) is a critical step for acceptability
and efficacy of this treatment during sleep in patients with chronic respiratory failure.
AIM: To study the variability of patient-ventilator interactions during the first nights
after initiation to NIV. Recorded data will be analyzed in part by dedicated tools from the
non-linear dynamics theory.
PATIENTS AND METHODS: Patients with chronic respiratory failure at stable state and
indicated to home NIV will be included. All patients will perform three polysomnographies
(under spontaneous breathing at D1 and under NIV at D2 and D15 after NIV initiation). All
ventilatory physiological data (pressure, flow, patient-ventilator interactions, oxygen
saturation, non intentional leaks) will be recorded during sleep under NIV in the Sleep
Laboratory of the Department and secondarily related to sleep architecture and quality of
sleep.
EXPECTED RESULTS: This study will identify objective parameters that are associated to a
satisfactory adaptation to nocturnal NIV.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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