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Chronic Renal Insufficiency clinical trials

View clinical trials related to Chronic Renal Insufficiency.

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NCT ID: NCT06362759 Recruiting - Clinical trials for Chronic Kidney Diseases

A Study to Evaluate TOUR006 in Patients With Chronic Kidney Disease and Elevated Hs-CRP

TRANQUILITY
Start date: May 15, 2024
Phase: Phase 2
Study type: Interventional

This study will evaluate the safety, tolerability, pharmacokinetics, and CRP-lowering effect of quarterly and monthly subcutaneous administration of TOUR006 in participants with chronic kidney disease and elevated hs-CRP.

NCT ID: NCT06046261 Completed - Clinical trials for Chronic Kidney Disease

Exploring the Impact of " ACP Board Game for Life" on Death Preparation and Anxiety in Patients With Stage 4 and 5 Chronic Kidney Diseases: A Pilot Study

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

This study was to explore the impacts of participating in "ACP board game for life" on death preparation, death anxiety, end-of-life care preferences, and intervention perception in stage 4-5 CKD patients with advanced chronic kidney diseases in a medical center.

NCT ID: NCT05735951 Recruiting - Clinical trials for Chronic Renal Insufficiency

Pharmacokinetic Parameters of Stiripentol in Renal Impaired Patients and Matching Controls With Normal Renal Function

STP237
Start date: July 24, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine whether the pharmacokinetics (PK) of stiripentol and of its relevant metabolites would be altered in subjects with renal impairment compared with normal controls in order to assess the need of dose adjustment in the renal impaired population. This study will include subjects with mild, moderate and severe renal impairment.

NCT ID: NCT04897672 Completed - Clinical trials for Congenital Heart Disease

2D-speckle Tracking in Pediatric Renal Chronic Disease

SPECKLEKIDNEY
Start date: May 1, 2021
Phase:
Study type: Observational

The SPECKLE- KIDNEY-PED is a multicentre observational controlled trial aiming to evaluate the 2D-Speckle tracking in a population of 85 patients aged from 6 to 17 years old with a chronic renal disease and to compare the results to those of 85 age and gender-matched healthy subjects. The secondary objective is to assess the conventional echocardiographic parameters and the level of exercice capacity.

NCT ID: NCT04364139 Completed - Clinical trials for Chronic Renal Insufficiency

African American Study of Kidney Disease and Hypertension

AASK
Start date: February 1, 1995
Phase: Phase 3
Study type: Interventional

The AASK is a multicenter, randomized, controlled clinical trial using a 2 × 3 factorial design to evaluate the effects of level of blood pressure control and type of anti-hypertensive medication on progression of chronic renal disease among African American men and women with chronic renal insufficiency caused by hypertension (hypertensive nephrosclerosis).

NCT ID: NCT04334707 Recruiting - Clinical trials for Chronic Kidney Diseases

Kidney Precision Medicine Project

KPMP
Start date: September 1, 2019
Phase:
Study type: Observational

Acute kidney injury (AKI) and chronic kidney disease (CKD) impose a significant global health burden. Yet, no effective therapies currently exist for AKI, and only a few are available for CKD. Despite significant effort from industry and academia, development of pharmacologic therapies for AKI and CKD has been hampered by: Non-predictive animal models The inability to identify and prioritize human targets The limited availability of human kidney biopsy tissue A poor understanding of AKI and CKD heterogeneity Historically, AKI and CKD have been described as single, uniform diseases. However, growing consensus suggests that different disease pathways lead to different subgroups of AKI and CKD (AKIs and CKDs). Access to human kidney biopsy tissue is a critical first step to define disease heterogeneity and determine the precise molecular pathways that will facilitate identification of specific drug targets and ultimately enable individualized care for people with AKI and CKD. A number of research centers across the United States are collaborating to bring state-of-the-art technologies together to: - Ethically obtain and evaluate kidney biopsies from participants with AKI or CKD - Define disease subgroups - Create a kidney tissue atlas - Identify critical cells, pathways, and targets for novel therapies The KPMP is made up of three distinct, but highly interactive, activity groups: - Recruitment Sites: The recruitment sites (RS) are responsible for recruiting participants with AKI or CKD into the longitudinal study and performing the kidney biopsy. - Tissue Interrogation Sites: The tissue interrogation sites (TIS) are responsible for developing and using innovative technologies to analyze the biopsy tissue. - Central Hub: The central hub is responsible for aggregating, analyzing, and visualizing the generated data and providing scientific, infrastructure, and administrative support for the KPMP consortium.

NCT ID: NCT04289038 Completed - Pruritus Clinical Trials

The Efficacy of VR and AR on Pruritus

Start date: April 1, 2021
Phase: N/A
Study type: Interventional

The research will be conducted randomly in order to determine the effect of VR and AR on pruritus symptom.

NCT ID: NCT04006093 Completed - Peritoneal Dialysis Clinical Trials

Apixaban in Subjects With Peritoneal Dialysis

ApiDP
Start date: December 8, 2019
Phase: Phase 1
Study type: Interventional

The primary objective of this study is to assess the pharmacokinetics of a single oral dose of apixaban (5mg) in participants with dialysis peritoneal versus participants with normal renal function.

NCT ID: NCT03189316 Terminated - Clinical trials for Chronic Renal Insufficiency

Anti-inflammatory Cells in Peritoneal Cavity

Start date: June 6, 2017
Phase: N/A
Study type: Interventional

Some subsets of lymphocytes are able to inhibit immune response and thus, could be used to control auto-immune diseases and transplant reject. In mice, the main source of those anti-inflammatory lymphocytes is the peritoneal cavity. No data are available in human. This study aims at exploring the presence of those anti-inflammatory lymphocytes in human peritoneal cavity and at determine how to expand those cells.

NCT ID: NCT02786849 Recruiting - Clinical trials for Chronic Kidney Diseases

Neuromuscular Electrical Stimulation During Hemodialysis in Peripheral Muscle Strength and Exercise Capacity

Start date: June 2015
Phase: N/A
Study type: Interventional

The objective of this study will be to evaluate the effects of neuromuscular electrical stimulation of high and low frequency and intensity, performed during hemodialysis (HD), on peripheral muscle strength, exercise capacity and muscle change and inflammation markers in patients with chronic kidney disease (CKD).