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Clinical Trial Summary

Although no single treatment has shown superiority, short-term pain relief may be offered via a targeted local corticosteroid injection (CSI), used often in combination with local anesthetic (LA), which may reduce plantar fasciitis symptoms for up to 1 month. Moreover, administering a CSI is relatively quick and easy for any Provider to perform, though it is not without potential deleterious side effects and risks, including fibroblast degradation, fat pad atrophy, skin depigmentation, and even plantar fascia rupture.


Clinical Trial Description

Research performed in other musculoskeletal disorders (e.g. lateral epicondylitis) suggest that the "method" (i.e peppering vs single bolus deposition) of injection is more favorable than the steroid itself, though evidence for this positive effect in plantar fasciitis is rather scarce. Injection via peppering is a minimally invasive percutaneous technique which involves repeatedly fenestrating the pathologic site (i.e. plantar fascia) via hypodermic needle insertion at the tender area, then sequentially injecting a substance, withdrawing, redirecting, and reinserting all without emerging from the skin. Though hypothetical, this technique is thought to disrupt the degenerative process of Plantar Fasciitis (PF), encouraging both localized bleeding and fibroblastic proliferation and stimulating a local inflammatory response that would trigger the body's own reparative mechanism, leading to recovery. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05868577
Study type Interventional
Source Wake Forest University Health Sciences
Contact Martha Holden
Phone 336-716-5457
Email mholden@wakehealth.edu
Status Recruiting
Phase Phase 1
Start date October 18, 2023
Completion date October 2024

See also
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Completed NCT06348017 - Frequency of Neuropathic Pain in Patients With Plantar Fasciitis
Recruiting NCT03938896 - PRP IN Planter Fascitis N/A
Recruiting NCT05032300 - Shear Wave Elastography Technology to Evaluate the Efficacy of ESW in the Treatment of Patients With Chronic Plantar Fasciitis N/A
Completed NCT05754697 - IASTM Versus PRT in Patients With Chronic PF N/A
Completed NCT00447876 - Study to Assess the Efficacy and Safety of Dysport® in the Treatment of Chronic Plantar Fasciitis Phase 2/Phase 3
Active, not recruiting NCT05162144 - Proximal Medial Gastriocnemius Recession for Chronic Plantar Fasciitis N/A