Dietary Soy Isoflavones In Chronic Pancreatitis

Status Completed

Clinical Trial Summary

Dietary Soy Isoflavones in Chronic Pancreatitis: Investigating the Anti-inflammatory Effects of Food Innovation Science on Gastrointestinal Disease

Clinical Trial Description

Management of pancreatic disorders imparts a major burden on healthcare costs, estimated at over 3 billion dollars annually. Chronic pancreatitis is characterized by chronic inflammation and progressive scarring, leading to abdominal pain, irreversible damage to the pancreas and the loss of both exocrine and endocrine function. Additionally, chronic pancreatic inflammation is a risk factor for pancreas cancer. There are no current treatments to modify the natural history of this disorder. Thus, identifying novel therapeutic options for this disease represents a high priority, and could fill an unmet medical need to improve quality of life, reduce risk of malignant transformation, and limit exorbitant medical costs associated with patient care. The investigators have assembled a multi-disciplinary research team to pursue an alternative, non-pharmacologic approach to limiting inflammatory cascades in (Chronic Pancreatitis) CP patients. They will assess compliance, toxicity and measure the changes in pro-inflammatory cytokine expression from a soy based dietary bread product using a classic 3+3 dose escalation study design in subjects with chronic pancreatitis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02577640
Study type	Interventional
Source	Ohio State University
Contact
Status	Completed
Phase	N/A
Start date	July 2015
Completion date	July 2017

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03112759` - Assessing the Utility of Cognitive Behavioral Therapy for Pain Control in Patients With Chronic Pancreatitis	N/A
Enrolling by invitation	`NCT05410795` - Establishment and Verification of Pancreatic Volume Formula Based on Imaging
Active, not recruiting	`NCT02965898` - The Effect of Vitamin D Substitution on the Development of Chronic Pancreatitis	N/A
Completed	`NCT02868047` - Establishing Standards for Normal Pancreatic EUS	N/A
Completed	`NCT01452217` - Non-invasive MRI to Quantify the Effect of Secretin on Pancreatic Blood Flow and Perfusion in Healthy Volunteers	Phase 1
Completed	`NCT00685087` - A Prospective Study of Natural History of Pancreatitis	N/A
Completed	`NCT04949828` - Effect of CREON on Exocrine Pancreatic Insufficiency (EPI) Symptoms
Recruiting	`NCT06068426` - Incorporating Endoscopic Ultrasound and Elastography Towards Improving Outcomes of Pediatric Pancreatitis Management	N/A
Active, not recruiting	`NCT05764629` - An Observational Study on Post-chronic Pancreatitis Diabetes Mellitus
Active, not recruiting	`NCT05042284` - Effect of Non-enteric Coated Enzymes Substitution on Pain in Patients With Chronic Pancreatitis	N/A
Completed	`NCT03850977` - Is There an Association Between Chronic Pancreatitis and Pulmonary Function
Recruiting	`NCT05692596` - The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics
Recruiting	`NCT06015945` - Role of Home-based Transcutaneous Electrical Acustimulation for Treatment of Pain in Patients With Chronic Pancreatitis	N/A
Completed	`NCT04619511` - Risk Factors for Post-ESWL and Post-ERCP Pancreatitis
Completed	`NCT03283566` - Hydroxychloroquine and Metabolic Outcomes in Patients Undergoing TPAIT	Phase 2
Recruiting	`NCT03434392` - QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing	N/A
Completed	`NCT01318369` - Efficacy Study of Δ9-THC to Treat Chronic Abdominal Pain	Phase 2
Completed	`NCT01430234` - Enzyme Suppletion in Exocrine Pancreatic Dysfunction	Phase 4
Terminated	`NCT01442454` - Endoscopic Ultrasound (EUS) Features of Chronic Pancreatitis	N/A
Completed	`NCT00755573` - Pain and Chronic Pancreatitis - Clinical End Experimental Studies	Phase 2/Phase 3