Chronic Nonhealing Wounds Clinical Trial
Official title:
Safety and Efficacy Study for the Use of Extracorporeal Shockwaves in the Treatment of Chronic Soft Tissue Wounds
Chronic soft tissue wounds represent a difficult problem for patients and doctors as well.
Chronic wounds can be caused by internal and dermatological diseases like venous ulcers as a
consequence of venous insufficiency, arterial ulcers as a consequence of peripheral
occlusive vascular disease, the diabetic foot stemming from diabetes and other pathologies.
A different reason for chronic wounds could be prior traumatic injuries (war wounds, traffic
accidents)not showing a tendency to heal after surgical repair.
The primary goal in the treatment of chronic soft tissue wounds is to obtain wound closure.
Usually necrotic tissue is debrided, i.e. surgically removed, to assess the full extent of
the damage, to detect underlying abscesses or other pathologies causing the non-healing of
the wound. Wet - to - wet dressings are primarily applied to induce a healing process. As
second line attempts to obtain closure special dressings like semipermeable films, gels,
hydrocolloids and calcium alginates are applied. These expensive dressings are associated
with extended time periods of conservative treatment until closure can be observed.
A third line after failure of nonoperative treatment is the application of skin graft. This
involves the operative and anesthesiological risk for an already health wise compromised
patient with little to no physiological reserve. One should not forget that the majority of
patients presenting at outpatient clinics with chronic soft tissue wounds are the elderly
with/without disabling comorbidities.
The use of extracorporeal shockwaves (ESW) for clinical applications was introduced in
central Europe more than two decades ago. Extracorporeal shockwave therapy (ESWT)is used in
the fields of urology, orthopedic surgery, trauma surgery. ESW are associated with the
induction of neovascularisation and with mechanical stimuli causing proliferation of a large
number of cells including osteoblasts (Martini L., J Trauma 2006). The exact effects of ESW
on human cells are currently studied in several centers worldwide. The application of ESWT
in the above mentioned fields of medicine proved safe, reliable and almost
complication-free.
Our center's experience with ESWT in trauma surgery (Schaden W., Clin. Orthop 2001)and the
observation that not only the traumatic condition (fracture non-union, etc.), but also the
surrounding tissue showed favorable tissue healing after ESWT, leads to our hypothesis that
ESWT might be beneficial for the much larger number of chronic soft tissue wounds. The
investigators anticipate to induce complete wound healing in a number of defined
clinical/pathological conditions by ESWT. At the same time efficacy and safety of ESWT will
be investigated.
n/a
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Withdrawn |
NCT01125735 -
MIST Therapy's Effectiveness in Wound Bed Preparation and Role of Bacterial Biofilm in Chronic, Non-healing Wounds
|
Phase 4 |