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Venetoclax After TKI to Target Persisting Stem Cells in CML — VARIANT  

Chronic Myeloid Leukemia Clinical Trial

Official title:
Venetoclax After TKI to Target Persisting Stem Cells in CML

Clinical Trial Summary

There is currently no available treatment, capable to increase the rate of sustained deep molecular remissions after TKI discontinuation in CML. Venetoclax could be such a drug. The study will provide unprecedented biological insights on the effects of venetoclax in controlling minimal residual stem cell disease induced by long-term prior TKI therapy. If the study would be positive, the findings could become practice changing for patients in deep molecular remission under TKI and willing to tolerate a temporary additional treatment.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05701215
Study type Interventional
Source University of Jena
Contact Thomas Ernst, Prof. Dr.
Phone +49 3641 Ext. 9396670
Email thomas.ernst@med.uni-jena.de
Status Recruiting
Phase Phase 2
Start date August 31, 2023
Completion date December 1, 2025
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