Effect of Auricular Vagus Nerve Stimulation in Women With Migraine Disease

Status Completed

Clinical Trial Summary

The aim of the study was to investigate the effectiveness of non-invasive auricular vagus nerve stimulation on pain and pulse variability in women aged 18-55 years with migraine. It is also aimed to see the effects of vagus nerve stimulation from all directions by making pain, pulse, blood pressure and autonomic measurements.

Clinical Trial Description

Migraine, a neurological disorder that causes severe disability, is characterized by recurrent moderate to severe attacks associated with vegetative symptoms. Patients with frequent attacks may overuse drugs, which can lead to migraine chronization and headache. In the last decade, neuromodulatory approaches have been developed for the treatment of headaches that do not respond adequately to treatment. Non-invasive neuromodulation techniques are an evolving field in migraine research and treatment. Non-invasive vagus nerve stimulation is one of the non-invasive neuromodulation techniques. Promising findings on vagus nerve stimulation in people with chronic pain, including migraine and cluster headaches, are slowly being recognized. Stimulation of the vagus nerve provides a way of regulating autonomic tone. Auricular vagus nerve stimulation regulates abnormal sympatho-vagal balance while activating the parasympathetic system, including anti-inflammatory pathways (cholinergic anti-inflammatory pathway and hypothalamic-pituitary adrenal axis). It is aimed to evaluate the effect on pain and pulse variability after vagus nerve stimulation in women with migraine disease and to learn how the vagus nerve crosses according to the pulse measurements taken from the right and left index fingers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05748535
Study type	Interventional
Source	Bahçesehir University
Contact
Status	Completed
Phase	N/A
Start date	June 6, 2022
Completion date	January 27, 2023

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT04520425` - Osteopathic Manipulative Techniques for the Treatment of Chronic Migraine Headaches	N/A
Recruiting	`NCT06247592` - Pulse Radiofrequency and Occipital Nerve Block for Chronic Migraine Patients	N/A
Recruiting	`NCT06133491` - Open Label, 6-month Study for High Frequency and Chronic Migraine,
Recruiting	`NCT04989413` - Cannabidiol 133mg + Cannabigerol 66mg + Tetrahydrocannabinol 4mg vs Placebo as Adjuvant Treatment in Chronic Migraine -	Phase 4
Recruiting	`NCT06138171` - Personality, Defences, Central Sensitization, and Trauma in Women With Chronic Migraine, Fibromyalgia, and Vulvodynia
Active, not recruiting	`NCT06109389` - The Efficacy Of Lidocaine Infusion IN Chronic Unilateral Migraine Headache	Phase 2
Completed	`NCT04871581` - Adjunctive Treatment of Chronic Migraine Using an Oral Dental Device	N/A
Withdrawn	`NCT01749423` - A Retrospective Study to Evaluate the Effectiveness of onabotulinumtoxinA in Preventing Headaches in Patients With Chronic Migraines	N/A
Terminated	`NCT04349176` - Onabotulinum Dose Comparison in Chronic Migraine Superior to 100 Units?	Phase 3
Completed	`NCT05381129` - The Effect of Accompanying Temporomandibular Joint Dysfunction in Patients With Chronic Migraine	N/A
Withdrawn	`NCT03465826` - Developing a Mobile Health Pain-Coping Skills Training Program for the Treatment of Chronic Migraine: AIM 4	N/A
Completed	`NCT05381012` - Fibromyalgia Syndrome on Patients With Chronic Migraine	N/A
Completed	`NCT03767062` - Peripheral Nerve Block and Topiramate in the Treatment of Medication Overuse Headaches	N/A
Recruiting	`NCT05724771` - COACT Study: CGRPmAbs + OnabotulinumtoxinA Assessment of Chronic Migraine Treatments Study	Phase 4
Recruiting	`NCT05313503` - KETOMIGRAINE: Ketogenic Diet in Drug-resistant Chronic Migraineurs	N/A
Recruiting	`NCT05079659` - Rate , Predictors and Outcome of Chronic Migraine
Completed	`NCT06118190` - Mesotherapy in the Treatment of Chronic Migraine	N/A
Completed	`NCT03698409` - Onabotulinumtoxin Type A Reconstitution With Preserved Versus Preservative-free Saline in Chronic Migraine.	Phase 4
Completed	`NCT04017741` - A Study Investigating the Efficacy of GON Blocks.	Phase 4
Completed	`NCT05679908` - A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine	Phase 2