Meditation for Older Adults With Chronic Low Back Pain

Status Not yet recruiting

Clinical Trial Summary

This pilot randomized controlled trial aims to recruit 66 community-dwelling older adults with chronic low back pain and follow up them for 8 weeks. This study aims to test the preliminary effect of a mindfulness-based meditation (MBM) intervention on pain and symptoms among community-dwelling older adults with chronic low back pain, and also to test the effect of the MBM intervention on the host Gut-Brain Axis (GBA).

Clinical Trial Description

Aim 1: to test the preliminary effect of a mindfulness-based meditation (MBM) intervention on pain and symptoms among community-dwelling older adults with chronic low back pain. Hypothesis: We hypothesize that our active mindfulness-based meditation intervention will be feasible and acceptable to community-dwelling older adults with chronic low back pain and improve pain and symptoms to a greater extent than older adults randomized to a sham mindfulness-based meditation group. Aim 2: to test the effect of the mindfulness-based meditation intervention on the host Gut-Brain Axis (GBA), and inflammatory cytokines (CRP, IL and TNF). Hypothesis: We hypothesize that older adults randomized to the active mindfulness-based meditation intervention will have significantly improved compositional patterns and functional profiles of gut microbiota and increased pain-related cortical response measured by functional near-infrared spectroscopy (fNIRS) to a greater extent than older adults randomized to the sham mindfulness-based meditation group at 2-weeks post-intervention, and 8-weeks follow up. We also hypothesize that older adults randomized to the active mindfulness-based meditation intervention will have significantly decreased inflammatory cytokines (CRP, IL and TNF) levels at 8-weeks follow up than older adults randomized to the sham mindfulness-based meditation group. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06384001
Study type	Interventional
Source	Florida State University
Contact	Jie Chen
Phone	(850) 645-0657
Email	jc22db@fsu.edu
Status	Not yet recruiting
Phase	N/A
Start date	May 2024
Completion date	December 2025

View Details

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