PRECISION Pain Research Registry

Chronic Low Back Pain Clinical Trial

— PRECISION  

Official title:

Pain Registry for Epidemiological, Clinical, and Interventional Studies and Innovation

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04853732
• Other study ID #: #2015-169
• Status: Recruiting
• Start date: April 2016
• Est. completion date: December 2030

Study information

• Verified date: January 2024
• Source: University of North Texas Health Science Center
• Contact: Cathleen Kearns, BA
• Phone: 817-735-0515
• Email: orcstudyoperations[@]unthsc.edu
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The PRECISION Pain Research Registry enrolls participants with chronic low back pain (cases) and participants who are free of chronic pain (controls) to study the epidemiology and management of chronic pain. The vision of the registry is to conduct research to provide a future for all unbounded by pain.

Description:

Case participants complete case report forms at quarterly encounters, whereas control participants complete a case report form only at an initial encounter.

A series of validated or recommended research instruments are used or adapted by the registry for deployment in its case report forms. These may include some or all of the following at a given encounter:

• National Institutes of Health Minimum Dataset for Research on Chronic Low Back Pain

• Roland-Morris Disability Questionnaire

• Patient-Reported Outcomes Measurement Information System (PROMIS-29)

• History of Medical Conditions Inventory

• Pain Sensitivity Questionnaire

• Pain Catastrophizing Scale

• Pain Self-Efficacy Questionnaire

• Non-Pharmacological Treatments Inventory

• Pharmacological Treatments Summary

• Drug Adverse Events Index

• Physician Profile

• Physician Communication Behavior Questionnaire

• Physician Consultation and Relational Empathy Measure

• Patient Satisfaction Questionnaire (PSQ-18)

These instruments include measures that may serve as the independent or dependent variables in various substudies conducted by the registry over time, including observational studies (e.g., case-control studies, cohort studies) and randomized controlled trials.

The registry also maintains a biobank of biological specimens that have been collected from enrolled participants, including saliva and blood that may be used for DNA sequencing or biomarker analysis.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 10000
• Est. completion date: December 2030
• Est. primary completion date: December 2030
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 21 Years to 79 Years

Eligibility

Inclusion Criteria:

• Must reside within the contiguous 48 United States or District of Columbia

• Must provide a valid, government-issued identification with photo and birthdate

• Must have Internet access or telephone service to communicate with registry staff

• Must have sufficient English language proficiency to complete case report forms independently or with assistance from registry staff

• Must have a primary care physician or other physician who regularly provides health care

• Must provide the name, dose, and frequency of use of all current medications

• Case participants must have chronic low back pain

• Control participants must be free of any chronic pain and may include healthy volunteers

Exclusion Criteria:

• Must not be pregnant

• Must not reside in an institutional facility

Related Conditions & MeSH terms

• Chronic Low Back Pain
• Low Back Pain

Locations

Country	Name	City	State
United States	University of North Texas Health Science Center	Fort Worth	Texas

Sponsors (1)

Lead Sponsor	Collaborator
University of North Texas Health Science Center

Country where clinical trial is conducted

United States, 

References & Publications (21)

Licciardone JC, Aryal S. Nonadherence to Clinical Practice Guidelines for Opioid Prescribing in Patients with Chronic Low Back Pain: A Pain Research Registry-Based Study. J Am Board Fam Med. 2022 Jul-Aug;35(4):724-732. doi: 10.3122/jabfm.2022.04.210432. — View Citation

Licciardone JC, Aryal S. Patient-centered care or osteopathic manipulative treatment as mediators of clinical outcomes in patients with chronic low back pain. J Osteopath Med. 2021 Aug 3;121(10):795-804. doi: 10.1515/jom-2021-0113. — View Citation

Licciardone JC, Beal J, Fakes N, Herron B, Jacobs C, Vasudevan A. The role of pain hypersensitivity in development of chronic widespread pain: a retrospective cohort study. Journal of Pain Management. January 2023;16(1):45-53.

Licciardone JC, Ganta S, Goehring L, Wallace K, Pu R. Analysis of the Patient-Physician Relationship, Race, and Pain Control and Physical Function Among Adults With Chronic Low Back Pain. JAMA Netw Open. 2022 Jun 1;5(6):e2216270. doi: 10.1001/jamanetworko — View Citation

Licciardone JC, Gatchel RJ, Aryal S. Effects of Opioids and Nonsteroidal Anti-Inflammatory Drugs on Chronic Low Back Pain and Related Measures: Results from the PRECISION Pain Research Registry. Tex Med. 2018 Oct 1;114(10):e1. — View Citation

Licciardone JC, Gatchel RJ. Osteopathic Medical Care With and Without Osteopathic Manipulative Treatment in Patients With Chronic Low Back Pain: A Pain Registry-Based Study. J Am Osteopath Assoc. 2020 Feb 1;120(2):64-73. doi: 10.7556/jaoa.2020.016. — View Citation

Licciardone JC, Kellerlee J, Joseph M, Mohammad MB, Kim KG, Jain J, Aryal S. The process and outcomes of chronic low back pain treatment provided by osteopathic and allopathic physicians: a retrospective cohort study. J Osteopath Med. 2023 May 25;123(8):3 — View Citation

Licciardone JC, McDonald H, Yablon M, Ngo W, Cunanan Garza KA, Aryal S. Optimizing chronic pain management through patient engagement with quality of life measures: a randomized controlled trial. J Osteopath Med. 2022 Aug 2;122(11):571-580. doi: 10.1515/j — View Citation

Licciardone JC, Miller CL, Nazzal AJ, Hernandez CT, Nguyen LH, Aryal S. Racial Disparities in Opioid Use and Lumbar Spine Surgery for Chronic Pain and in Pain and Function Over 3 Years: A Retrospective Cohort Study. J Pain. 2023 Sep 28:S1526-5900(23)00547 — View Citation

Licciardone JC, Moore S, Fix K, Blair LG, Ta K. Osteopathic manipulative treatment of patients with chronic low back pain in the United States: a retrospective cohort study. J Osteopath Med. 2023 Feb 3;123(5):259-267. doi: 10.1515/jom-2022-0212. eCollecti — View Citation

Licciardone JC, Pandya V. Feasibility Trial of an eHealth Intervention for Health-Related Quality of Life: Implications for Managing Patients with Chronic Pain during the COVID-19 Pandemic. Healthcare (Basel). 2020 Oct 1;8(4):381. doi: 10.3390/healthcare8 — View Citation

Licciardone JC, Pandya V. Pain and functional recovery from chronic low back pain over 12 months: implications for osteopathic medicine. J Osteopath Med. 2022 Aug 24;122(12):623-630. doi: 10.1515/jom-2021-0288. eCollection 2022 Dec 1. — View Citation

Licciardone JC, Pandya V. Prevalence and Impact of Comorbid Widespread Pain in Adults with Chronic Low Back Pain: A Registry-Based Study. J Am Board Fam Med. 2020 Jul-Aug;33(4):541-548. doi: 10.3122/jabfm.2020.04.190456. — View Citation

Licciardone JC, Pandya V. Use of Complementary Health Approaches for Chronic Low-Back Pain: A Pain Research Registry-Based Study. J Altern Complement Med. 2020 May;26(5):369-375. doi: 10.1089/acm.2019.0448. Epub 2020 Mar 11. — View Citation

Licciardone JC, Patel S, Kandukuri P, Beeton G, Nyalakonda R, Aryal S. Patient Satisfaction With Medical Care for Chronic Low Back Pain: A Pain Research Registry Study. Ann Fam Med. 2023 Mar-Apr;21(2):125-131. doi: 10.1370/afm.2949. — View Citation

Licciardone JC, Schmitt ME, Aryal S. Empathy in Medicine Osteopathic and Allopathic Physician Interpersonal Manner, Empathy, and Communication Style and Clinical Status of Their Patients: A Pain Registry-Based Study. J Am Osteopath Assoc. 2019 Aug 1;119(8 — View Citation

Licciardone JC. Assessment of Longitudinal Clinical Outcome Measures for Chronic Low Back Pain over 12 Months. J Gen Intern Med. 2020 Dec;35(12):3733-3735. doi: 10.1007/s11606-020-05723-3. Epub 2020 Feb 19. No abstract available. — View Citation

Licciardone JC. Demographic Characteristics Associated With Utilization of Noninvasive Treatments for Chronic Low Back Pain and Related Clinical Outcomes During the COVID-19 Pandemic in the United States. J Am Board Fam Med. 2021 Feb;34(Suppl):S77-S84. do — View Citation

Licciardone JC. Impact of COVID-19 on utilization of nonpharmacological and pharmacological treatments for chronic low back pain and clinical outcomes. J Osteopath Med. 2021 Mar 29;121(7):625-633. doi: 10.1515/jom-2020-0334. — View Citation

Licciardone JC. Preventing progression from chronic to widespread pain and its impact on health-related quality of life: a historical cohort study of osteopathic medical care. J Osteopath Med. 2021 Sep 23;122(1):21-29. doi: 10.1515/jom-2021-0105. — View Citation

Schultz MJ, Licciardone JC. The effect of long-term opioid use on back-specific disability and health-related quality of life in patients with chronic low back pain. J Osteopath Med. 2022 Aug 11;122(9):469-479. doi: 10.1515/jom-2021-0172. eCollection 2022 — View Citation

* Note: There are 21 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Case-Control Status	Chronic Low Back Pain Case or Chronic Pain-Free Control	Upon registry enrollment

External Links

•   Participant screening site (cases)