Changes in Motor Cortex Following Exercises for Chronic Low Back Pain

Status Completed

Clinical Trial Summary

The motor cortex of the brain changes following chronic pain and injury, and this is linked to pain-associated changes in motor behaviour. This study aimed to investigate whether therapeutic exercises in patients with chronic pain can induce reorganisation of the motor cortex and restore normal motor behaviour. The investigators hypothesised that motor training can induce reorganisation of the motor cortex and that these changes are related to improved motor behaviour.

Clinical Trial Description

The sensory and motor systems can reorganize following injury and learning of new motor skills. Recently we observed adaptive changes in motor cortical organization in patients with chronic back pain, which are closely linked to changes in motor behavior. Although pain-related alterations in behavior can be trained and are associated with improved symptoms, it remains unclear whether these meaningful functional outcomes are related to motor cortical reorganization. Here we investigate the effects of two interventions in people with chronic back pain: skilled motor training and a control intervention of self-paced walking exercise. We measured motor cortical excitability (motor threshold (MT)) and organization (center of gravity (CoG) and map volume) of the deep abdominal muscle, transversus abdominis (TrA), using transcranial magnetic stimulation (TMS). In addition, motor behavior of TrA was assessed during single rapid arm movements. The study helps to elucidate the mechanisms of specific motor exercises in chronic back pain management. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00864422
Study type	Interventional
Source	The University of Queensland
Contact
Status	Completed
Phase	Phase 1
Start date	October 2006
Completion date	September 2007

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03243084` - Transcranial Alternating Current Stimulation in Back Pain- Pilot Sudy	N/A
Suspended	`NCT04735185` - Stem Cells vs. Steroids for Discogenic Back Pain	N/A
Completed	`NCT03162952` - RAND Center of Excellence for the Study of Appropriateness of Care in CAM
Completed	`NCT03240146` - Pulsed Shortwave Therapy Treatment for Chronic Musculoskeletal Low Back Pain	N/A
Completed	`NCT05282589` - Lumbopelvic Manipulation Effects on Fatigue in Chronic Low Back Pain Patients	N/A
Completed	`NCT03637998` - Physical Activity on Neurophysiologic Gene Expression Profiles of Chronic Low Back Pain	N/A
Recruiting	`NCT02289170` - Clinical Study to Evaluate the Safety and Efficacy of Heating and Cooling Combination Therapeutic Device(OCH-S100)	N/A
Active, not recruiting	`NCT01944163` - The IMPACT of a Referral Model for Axial Spondyloarthritis in Young Patients With Chronic Low Back Pain	N/A
Completed	`NCT02231554` - Feldenkrais vs Back School for Treating Chronic Low Back Pain: a Randomized Controlled Trial	N/A
Recruiting	`NCT02063503` - Identification of Prognostic Indicators for Rehabilitation in Chronic Nonspecific Low Back Pain Patients	N/A
Terminated	`NCT01620775` - MR(Magnetic Resonance) Imaging of Neurotransmitters in Chronic Pain	N/A
Completed	`NCT01704677` - Lumbar Disc Prosthesis Versus Multidisciplinary Rehabilitation; 8-year Follow-up	N/A
Completed	`NCT01177241` - Cytochrome P450 Pharmacokinetic DDIs Among Patients With Chronic Low Back Pain Taking Opioids	N/A
Completed	`NCT01177280` - Prevalence of Potential Cytochrome P450 Pharmacokinetic Incident Drug-Drug Interactions Among Chronic Low Back Pain Patients Taking Opioid Analgesics and Associated Economic Outcomes	N/A
Completed	`NCT01177254` - Exposure to Potential Cytochrome P450 Pharmacokinetic Drug-Drug Interactions Among Osteoarthritis Patients: Incremental Risk of Multiple Prescriptions	N/A
Completed	`NCT01490905` - A Double Blind Placebo Study to Determine the Effectiveness of Theramine on the Management of Chronic Back Pain	Phase 4
Completed	`NCT00984815` - Safety Study of HZT-501 in Patients Who Require Long-Term Daily Non-steroidal Anti-inflammatory Drug Treatment	Phase 3
Completed	`NCT00763321` - Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP)	Phase 3
Completed	`NCT00767806` - A Study for Patient With Chronic Low Back Pain	Phase 3
Completed	`NCT00761150` - Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP)	Phase 3