Chronic Liver Disease Clinical Trial
Official title:
Comparison Between Thromboelastography and Conventional Coagulation Tests in Pediatrics With Chronic Liver Disease
- Compare between thromboelastography (TEG) and conventional coagulation tests (CCT) in children with chronic liver disease who admitted to Assiut University Children Hospital. - Detect the advantages of TEG in predicting the risk of bleeding, assessing haemostasis and guiding blood product transfusion for each coagulation defect .
Status | Not yet recruiting |
Enrollment | 33 |
Est. completion date | March 31, 2024 |
Est. primary completion date | March 31, 2024 |
Accepts healthy volunteers | |
Gender | All |
Age group | 6 Months to 18 Years |
Eligibility | Inclusion Criteria: - Patients with chronic liver disease of any aetiology as (congenital hepatic fibrosis, liver cirrhosis, autoimmune hepatitis, Wilson disease, metabolic liver disease and others ). - Patients aged 6m- 18y . Exclusion Criteria: - Patients who received transfusion of blood products within 48hr prior to sample collection. - Patients who are on therapy with antiplatelet drugs or anticoagulants. - Patients with history of primary disease with coagulation disturbance (paroxysmal nocturnal hemoglobinuria, polycythemia, idiopathic thrombocytopenia, haemophilia. - Patients with concomitant chronic kidney disease. |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Assiut University |
Amitrano L, Guardascione MA, Brancaccio V, Balzano A. Coagulation disorders in liver disease. Semin Liver Dis. 2002 Feb;22(1):83-96. doi: 10.1055/s-2002-23205. — View Citation
Chronic hepatitis and autoimmune chronic active hepatitis. In: Alex P.Movat (eds). Liver disorders in childhood 3rd edition. Oxford, Butterworth- Heinemann Ltd, 1994, pp. 180-96.
He Y, Yao H, Ageno W, Mendez-Sanchez N, Guo X, Qi X. Review article: thromboelastography in liver diseases. Aliment Pharmacol Ther. 2022 Aug;56(4):580-591. doi: 10.1111/apt.17080. Epub 2022 Jun 14. — View Citation
Janko N, Majeed A, Kemp W, Roberts SK. Viscoelastic Tests as Point-of-Care Tests in the Assessment and Management of Bleeding and Thrombosis in Liver Disease. Semin Thromb Hemost. 2020 Sep;46(6):704-715. doi: 10.1055/s-0040-1715475. Epub 2020 Sep 15. — View Citation
Sharma A, Nagalli S. Chronic liver disease. InStatPearls [Internet] 2021 Nov 25. StatPearls Publishing.
Versteeg HH, Heemskerk JW, Levi M, Reitsma PH. New fundamentals in hemostasis. Physiol Rev. 2013 Jan;93(1):327-58. doi: 10.1152/physrev.00016.2011. — View Citation
Viral hepatitis/Chronic hepatitis/Portal hypertension. In: Sherlock S, Dooley J, (eds). Diseases of liver and biliary system 10th edition. Oxford, Blackwell Science Ltd, 1997, pp. 162-3, 265-333.
Yang LL. Anatomy and Physiology of the Liver. Anesthesia for Hepatico-Pancreatic-Biliary Surgery and Transplantation. 2021:15-40.
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Detect the clotting time, clotting kinetics and clot stability | By thromboelastography parameters | Baseline | |
Primary | compare between thromboelastography and conventional coagulation tests | in evaluation of haemostatic status in pediatrics with chronic liver disease . | Baseline | |
Primary | Detect the advantages of thromboelastography | predicting the risk of bleeding, assessing haemostasis and guiding blood product transfusion for each coagulation defect . | Baseline |
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