Wasting in Chronic Kidney Disease

Chronic Kidney Hospitalized Clinical Trial

— PEW  

Official title:

Wasting in Chronic Kidney Disease: Refeeding Techniques and Artificial Nutrition Practices

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03135717
• Other study ID #: 69HCL14-253
• Status: Completed
• Phase: N/A
• First received: April 24, 2017
• Last updated: April 26, 2017
• Start date: December 2011
• Est. completion date: June 2012

Study information

• Verified date: April 2017
• Source: Hospices Civils de Lyon
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Protein energy wasting is an independent factor associated with morbi-mortality in chronic kidney disease. Wasting is particularly common in chronic diseases of organs such as kidney disease with a major impact at the stage of dialysis. It covers 20 to 70% of patients diagnosed with chronic kidney disease according to the degree of evolution of the disease and the diagnostic method.

Mechanisms of PEW are based mainly on anorexia and metabolic abnormalities caused by kidney disease. Nutritional treatment differs depending on the stage of the kidney disease acute or chronic treated whether or not by dialysis. Nutritional monitoring should be regular, individualized and collaborative to detect a risk of PEW or treat installed PEW. Refeeding techniques should allow all the nutritional needs. Their indications depend on the clinic, biochemical assessment and nutrient intake.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 48
• Est. completion date: June 2012
• Est. primary completion date: June 2012
• Accepts healthy volunteers: No
• Gender: All
• Age group: 44 Years to 73 Years

Eligibility

Inclusion Criteria:

• Patients with kidney disease

• Patients hospitalized in a university hospital renal ward

Exclusion Criteria:

• Hospitalization less than two weeks

Related Conditions & MeSH terms

• Cachexia
• Chronic Kidney Hospitalized
• Kidney Diseases
• Renal Insufficiency, Chronic

Intervention

Dietary Supplement:
• Nutritional care
Diagnosis of protein energy wasting : anthropometry, calculation of the nutrient intakes, evaluation of appetite, evaluation of gastrointestinal syndromes, hand grip test and bioimpedancemetry Treatment of protein energy wasting : estimation of nutritional requirements, prescription of oral nutritional supplement or artificial nutrition, physical rehabilitation Multidisciplinary approach (nephrologists, dieticians, physiotherapists, nurses) Evaluation of the nutritional treatment (plasma albumin and prealbumin, weight evolution, muscle strength and body composition)

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Nutritional care evaluated with questionnaire		Since admissions to hospital, up to 4 weeks
Secondary	body composition		Since admissions to hospital, up to 4 weeks
Secondary	physical activity		Since admissions to hospital, up to 4 weeks