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Pyrophosphate and Arterial Calcification in Chronic Kidney Disease — Predical  

Chronic Kidney Diseases Clinical Trial

Official title:
Pyrophosphate: a New Biomarker to Predict Arterial Calcification in Chronic Kidney Disease

Clinical Trial Summary

Arterial calcifications start at early stages of chronic kidney disease (CKD) and are associated to cardiovascular mortality. Pyrophosphate (PPi) is an endogenous compound, which stops the mineralization process in bones and is expected to act at ectopic sites. In uremic rats, low PPi plasma levels are associated with high calcium content in the aorta and peritoneal administration of PPi blocks this process. People on maintenance dialysis or kidney transplant recipients have low plasma levels of PPi and show high scores of arterial calcification. The purpose is to determine the role of low PPi in the development of arterial calcifications in patients with CKD stage 3 or 4. To that aim, 252 patients with eGFR between 59 et 20 ml/min/1,73 m2 will be recruited and will be examined at baseline and three years later.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04950439
Study type Interventional
Source Centre Hospitalier Universitaire de Nice
Contact Favre Guillaume, PhD
Phone 0492038428
Email favre.g@chu-nice.fr
Status Recruiting
Phase N/A
Start date March 14, 2022
Completion date March 14, 2028
View Details
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