Chronic Kidney Disease-Mineral and Bone Disorder Clinical Trial
Official title:
To Investigate the Bone and Muscle Abnormalities in Patients With Chronic Kidney Disease Compared to Healthy Volunteers With MRI
Patients with chronic kidney disease (CKD) have a higher risk of fractures than those without. The purpose of this study is to develop a non-invasive Magnetic resonance imaging (MRI) method that can improve fracture risk prediction and provide early diagnosis for bone abnormalities in patients with CKD.
Chronic Kidney Disease-Mineral and Bone Disorder (MBD） is a common complication of chronic
kidney disease (CKD), which may lead to defective mineralization, altered bone morphology,
and/or bone turnover. Animal research found that bone changes occur even in the early stage
of CKD , and with CKD progression, the patient may show symptoms such as bone pain, joint
pain, bone deformation, and even spontaneous fractures.
Despite significant advances in understanding bone disease in CKD, most clinical and
biochemical targets used in clinical practice remain controversial, resulting in an
undermanagement of bone fragility.Our ability to diagnose CKD-MBD and to initiate strategies
that could prevent fractures remains limited by the lack of accurate and noninvasive
diagnostic tools.
The purpose of this study is to develop a non-invasive method that can improve fracture risk
prediction and provide early diagnosis for bone abnormalities in patients with CKD.
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