Chronic Kidney Disease Clinical Trial
Official title:
Prospective Evaluation of Serum Klotho, a Novel Biomarker, as a Predictor of Progression of Cardiovascular Calcification (CVC) in Chronic Kidney Disease (CKD)
This prospective observational study aims to investigate the relationship between CVC and serum Klotho for renal function correction in patients with different CKD stages
In this study, we plan to enroll 400 non-dialysis patients with CKD 2-5 and 300 maintenance
hemodialysis patients. Participants will receive coronary artery computed tomography (CT)
scanning to detect the extent and the severity of CVC. Follow-up is scheduled at 0, 6, 12,
18, and 24 months and will consist the following: routine physical examinations, standard lab
panels (blood routine, liver/kidney functions, tests of the coagulation system, etc.), total
calcium, phosphate, parathyroid hormone (PTH), serum 25(OH) vitamin D, fibroblast growth
factor-23 (FGF-23) and coronary artery computed tomography (CT).
The purpose of this study was to clarify the relationship between CVC in patients with
different CKD stages and serum Klotho for renal function correction, and to clarify that
Klotho can be used as an early biomarker for CVC in patients with CKD, so as to predict the
occurrence and progress of CVC.
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