Chronic Kidney Disease Clinical Trial
— PIPALOfficial title:
Arterial Calcifications: Role of Tissue-nonspecific Alkaline Phosphatase in Phosphate and Pyrophosphate Homeostasis. PIPAL Study.
Verified date | April 2024 |
Source | Centre Hospitalier Universitaire de Nice |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Vascular calcification is a common finding in chronic kidney disease and increases arterial stiffness leading to augmented cardiovascular morbidity. The calcification process is thoroughly regulated by pro and anticalcifying agents. The investigators hypothesize that imbalance in these compounds could depend on alkaline phosphatase activity. Therefore, the investigators will measure ALP activity, calcifications score, arterial stiffness and perform a bio-collection in monogenic rare diseases characterized by various levels of anticalcifying agents and in diverse CKD stages characterized by various levels of procalcifying compounds.
Status | Completed |
Enrollment | 35 |
Est. completion date | September 6, 2019 |
Est. primary completion date | September 6, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - patient with Chronic kidney disease (stage 1 or 2, 6 weeks after graft or patients on maintenance dialysis) or patient with pseudoxanthoma elasticum or patient with hypophosphatasia - informed consent signed Exclusion Criteria: - cancer - pregnancy |
Country | Name | City | State |
---|---|---|---|
France | CHU d'Angers - Service de Dermatologie | Angers | |
France | Service de Médecine Vacsulaire - CHU d'ANGERS | Angers | |
France | CHU de Nice | Nice | |
France | Service de Rhumatologie - Hôpital Cochin | Paris |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Universitaire de Nice |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | ALP activity (alkaline phosphatase activity) | ALP activity will be plotted against the PPi/Pi ratio in CKD patients with various Pi levels; a regression curve will be used to measure the correlation between these two factors | at time = day 0 (inclusion) |
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