Resistance Exercise Training in Chronic Kidney Disease

Chronic Kidney Disease Clinical Trial

Official title:

Effect of Resistance Exercise Training on Endothelial Function and Cardiovascular Risk Factors in Patients With Chronic Kidney Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03120416
• Other study ID #: 2016-0421
• Secondary ID: K23DK094829
• Status: Completed
• Phase: N/A
• Start date: January 25, 2017
• Est. completion date: July 31, 2018

Study information

• Verified date: April 2019
• Source: University of Illinois at Chicago
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators aim to evaluate the feasibility of a resistance exercise training program among individuals with CKD and its impact on endothelial and vascular function.

Description:

Resistance exercise training has been shown to improve cardiovascular health including endothelial function in general populations, but studies in patients with chronic kidney disease (CKD) are limited. The investigators aim to evaluate the feasibility and acceptability of a resistance exercise training program among individuals with CKD and its impact on endothelial and vascular function as measured by brachial artery flow-mediated dilation, pulse-wave velocity and carotid artery stiffness. To accomplish this goal the investigators propose to conduct a 12-week pilot randomized controlled trial of twice a week resistance exercise training among 32 adults with CKD. The results of this study will inform the design and implementation of a larger trial evaluating the impact of resistance exercise training on adverse outcomes in patients with CKD including CKD progression.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 34
• Est. completion date: July 31, 2018
• Est. primary completion date: July 31, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 21 Years and older

Eligibility

Inclusion Criteria:

• CKD stage 3 or 4 (eGFR 15-60 ml/min/1.73m2)

Exclusion Criteria:

• Currently institutionalized

• Kidney transplant or dialysis

• NY Heart Association class 3-4 heart failure

• Dementia or cognitive impairment

• Unstable angina or coronary revascularization within the last 3 months

• Uncontrolled arrhythmia

• Severe chronic lung disease

• Orthopedic, neurologic or other condition that would preclude resistance exercise training

• Pregnancy

• Uncontrolled hypertension (systolic > 160 mmHg and diastolic >90 mmHg)

Related Conditions & MeSH terms

• Chronic Kidney Disease
• Kidney Diseases
• Renal Insufficiency, Chronic

Intervention

Behavioral:
• Resistance exercise training
12-week resistance exercise training program, 2 times per week, 45 min per session. Eight exercises will be used to include large upper and lower body muscle groups (leg press, leg extension, leg curl, chest press, shoulder extension, biceps curl, abdominal crunch and back extension). The baseline one repetition maximum will be used to set initial training loads.

Locations

Country	Name	City	State
United States	University of Illinois at Chicago	Chicago	Illinois

Sponsors (3)

Lead Sponsor	Collaborator
University of Illinois at Chicago	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Endothelial function	Measured by brachial artery flow-mediated dilation (FMD)	3 months
Secondary	Vascular function	Measured by pulse wave velocity	3 months
Secondary	Carotid artery stiffness	Measured by non-invasive ultrasound	3 months
Secondary	Self-reported physical activity	Assessed by the MESA (Multiethnic Study of Atherosclerosis) Typical Week Physical Activity Survey	3 months
Secondary	Objectively measured physical activity	Assessed by a physical activity monitor (ActiGraph GT3X+)	3 months
Secondary	Systolic blood pressure	Measured using standard procedures	3 months
Secondary	Serum LDL-cholesterol	Measured using standard procedures	3 months
Secondary	Serum HDL-cholesterol	Measured using standard procedures	3 months
Secondary	Muscle strength	Assessed by the amount of weight lifted in a single chest press and leg press (1 RM).	3 months