Applications of MRI in Kidney Disease

Chronic Kidney Disease Clinical Trial

Official title:

Applications of MRI in Kidney Disease

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT02832505
• Other study ID #: 1603M85321
• Status: Not yet recruiting
• Start date: October 30, 2024
• Est. completion date: August 30, 2025

Study information

• Verified date: February 2024
• Source: University of Minnesota
• Contact: Xiufeng Li
• Phone: 612-625-7872
• Email: lixx1607[@]umn.edu
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study has two major purposes:

1. To test developed multiple anatomic and functional MRI methods;

2. To evaluate the potentials of these MRI methods in the diagnosis, prognosis, and monitoring of the progression of renal dysfunction.

These purposes will be achieved by performing pilot studies with cohorts of patients.

Description:

This study is observational with no intervention applied for the patients. In this study, multiple anatomic and functional MRI methods will be performed with three cohorts of patients. In addition to anatomic MRI methods, non-contrast enhanced functional MRI methods will also be applied to evaluate tissue perfusion and vascular reactivity in these patients.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 72
• Est. completion date: August 30, 2025
• Est. primary completion date: August 30, 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 45 Years and older

Eligibility

Inclusion Criteria:

1. English-speaking as primary language

2. Able to complete an approximately 75 to 90 minute cognitive and/or physical tests

3. Capable to consent to studies

Exclusion Criteria:

1. Acute psychiatric illness that would impede cognitive testing

2. Active chemical dependence, such as alcohol, narcotics or other drugs

3. Legally blind or unable to complete cognitive tests due to visual loss or deafness

4. Renal transplant recipient at time of screening or baseline

5. Severe CI unable to complete the Modified Mini-Mental State Examination [3MSE]

6. Chronic and acute pulmonary disease

Related Conditions & MeSH terms

• Chronic Kidney Disease
• End-stage Kidney Disease
• Kidney Diseases
• Kidney Failure, Chronic
• Renal Insufficiency, Chronic

Intervention

Other:
• No intervention but only observational
This study is a cross-sectional and observational MRI study with three cohorts of patients, and no interventions will be applied.

Locations

Country	Name	City	State
United States	University of Minnesota Medical Center	Minneapolis	Minnesota

Sponsors (1)

Lead Sponsor	Collaborator
University of Minnesota

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	MRI measured perfusion for each patient group	MRI measurements will be summarized for each patient group by using mean and standard deviation or standard error.	Baseline