The Effects of Dietary Fiber in CKD: A Systematic Review and Meta-analysis

Chronic Kidney Disease Clinical Trial

Official title:

The Effects of Dietary Fiber on Uremic Retention Solutes in CKD: A Systematic Review and Meta-analysis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01844882
• Other study ID #: SMH-CKD-2013
• Status: Completed
• Phase: N/A
• First received: April 29, 2013
• Last updated: November 20, 2014
• Start date: January 2012
• Est. completion date: August 2013

Study information

• Verified date: November 2014
• Source: St. Michael's Hospital, Toronto
• Contact: n/a
• Is FDA regulated: No
• Health authority: Canada: Ethics Review Committee
• Study type: Observational

Clinical Trial Summary

Chronic kidney disease (CKD) is a debilitating condition in which there is a gradual decline of renal function associated with increased overall mortality. Most dietary guidelines for CKD focus on limiting protein intake (nitrogen) and high phosphorus-containing foods. However, increasing dietary fiber has been proposed to increase fecal nitrogen excretion which may ameliorate the progress of CKD. We therefore plan to conduct a systematic review and meta-analysis on clinical trials to assess the effect of fiber on urea and creatinine as classical markers of a state of uremia in individuals with CKD. We hypothesize that increasing fiber intakes will improve urea and creatinine levels in individuals with CKD.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1
• Est. completion date: August 2013
• Est. primary completion date: August 2013
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Dietary trials in humans

• Randomized treatment allocation

• Suitable control (low fiber)

• viable endpoint data

Exclusion Criteria:

• Non-human studies

• Nonrandomized treatment allocation

• Lack of a suitable control (high protein)

• no viable endpoint data

Study Design

Time Perspective: Retrospective

Related Conditions & MeSH terms

• Chronic Kidney Disease
• Kidney Diseases
• Renal Insufficiency, Chronic

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
St. Michael's Hospital, Toronto

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Creatinine		1.5 years	No
Primary	urea		1.5 years	No
Secondary	Phosphorus		1.5 years	No