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NCT01770847 Clinical Trial

Arterial Stiffness in Chronic Kidney Disease

Chronic Kidney Disease Clinical Trial

Official title:
Diurnal Variations in Arterial Stiffness in Patients With Chronic Kidney Disease and Healthy Age Matched Controls

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01770847
Other study ID # 12\SS\0088
Secondary ID
Status Completed
Phase N/A
First received November 28, 2012
Last updated November 14, 2017
Start date November 2012

Study information
Verified date November 2017
Source University of Edinburgh
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Diurnal variations in the cardiovascular system apparent in healthy individuals, are different in chronic kidney disease patients. Therefore, diurnal variations in arterial stiffness may also differ in chronic kidney disease patients. This study aims to identify and evaluate diurnal variations in arterial stiffness in chronic kidney disease patients and compare them to those in age matched healthy controls.

Recruitment information / eligibility
Status Completed
Enrollment 50
Est. completion date
Est. primary completion date December 2013
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 79 Years
Eligibility Inclusion Criteria:

- Systolic blood pressure <160 whether or not on antihypertensive medication

- diastolic blood pressure <100mmHg whether or not on antihypertensive medication

- Chronic kidney disease stage 2-5

Exclusion Criteria:

- Systolic blood pressure =160mmHg

- Diastolic blood pressure =100mmhg

- Significant comorbidity (investigator opinion but to include alcoholism and terminal illness)

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United Kingdom Clinical Research Centre, 2nd Floor Western General Hospital Edinburgh

Sponsors (1)
Lead Sponsor Collaborator
University of Edinburgh

Country where clinical trial is conducted

United Kingdom, 

Outcome
Type Measure Description Time frame Safety issue
Primary Diurnal variations in arterial stiffness The principal objective of this study is to evaluate whether diurnal variations in arterial stiffness are blunted in chronic kidney disease compared to healthy age matched controls Over one 26 hour period arterial stiffness measurements will be obtained every 30 minutes from 7am to 12am and every 60 minutes from 12am to 7am
Secondary Diurnal variations in aortic and brachial blood pressure Secondary objective of this study is to evaluate whether diurnal variations in aortic and brachial blood pressure are blunted in chronic kidney disease compared to healthy age matched controls Over one 26 hour period blood pressure measurements will be obtained every 30 minutes from 7am to 12am and every 60 minutes from 12am to 7am
Secondary Relationship between changes in blood pressure and arterial stiffness Secondary objective of this study is to evaluate whether diurnal variations in arterial stiffness are dependent on changes in blood pressure in both chronic kidney disease patients and age matched controls. Over one 26 hour period
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