Chronic Kidney Disease Clinical Trial
Official title:
The Water Intake Trial: Pilot Phase
The investigators are conducting a six-week randomized controlled pilot trial to assess the
feasibility and safety of increased water intake in patients with chronic kidney disease.The
investigators will study 30 patients (age 30 to 80 with an estimated glomerular filtration
rate between 30 and 60 ml/min/1.73m2 and microalbuminuria [albumin to creatinine ratio >2.8
mg/mmol (if female) or >2.0 mg/mmol if male)].The investigators will randomize patients (in
a 2:1 ratio) to a fluid-intervention group or control group. Participants who are randomized
to the hydration-intervention group will be asked to consume 1.0 to 1.5 L water per day
(depending on sex and weight) in addition to usual consumed beverages, for 6 weeks.
Participants in the control group will be advised to consume their usual amount of fluid.
The investigators hypothesize that patients will be able to increase and maintain a higher
fluid intake with stable blood chemistry, particularly serum sodium.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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