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NCT01317173 Clinical Trial

Factors Related to the Progression of Chronic Kidney Disease

Chronic Kidney Disease Clinical Trial

Official title:
The Impact of FGF23 and Klotho on Progression of Chronic Kidney Disease

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT01317173
Other study ID # NEPH001
Secondary ID
Status Active, not recruiting
Phase N/A
First received March 16, 2011
Last updated March 16, 2011
Start date March 2008
Est. completion date June 2011

Study information
Verified date January 2011
Source Ankara Education and Research Hospital
Contact n/a
Is FDA regulated No
Health authority Turkey: Ethics Committee
Study type Observational

Clinical Trial Summary

Chronic kidney disease is a progressive disorder that has been influenced with many factors. Most of the patients has altered Ca P metabolism and these dis orders are the contributing factors of the disease progression. It has been recently documented that FGF23 and Klotho are the key factors of PTH secretion Ca-P metabolism. This study aimed to evaluate the impact of Klotho and FGF23 on the progression of stage 3-4 chronic kidney disease.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 90
Est. completion date June 2011
Est. primary completion date May 2011
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria:

- Non-diabetic chronic kidney disease

Exclusion Criteria:

- Presence of DM

- Actively using calcium based phosphorus binder of vitamin D

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Turkey Ankara Education and Research Hospital Ankara

Sponsors (1)
Lead Sponsor Collaborator
Ankara Education and Research Hospital

Country where clinical trial is conducted

Turkey, 

Outcome
Type Measure Description Time frame Safety issue
Primary Progression of kidney disease Doubling of creatinin, requirement of renal replacement therapy continuous measurement of kidney functions 3 monthly for two years or until the outcome reached Yes
Secondary Evaluation of Ca P metabolism Determination of Ca-P metabolism disorders. 3 monthly for two years or until the outcome reached No
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