Chronic Kidney Disease Clinical Trial
Official title:
Does a Reduction in Renal Function Increase Arterial Stiffness and Left Ventricular Mass? - A Prospective Study of Kidney Donors
Studies of patients with established kidney disease, even when this is mild, appear to show
that they are at high risk of heart failure, stroke and sudden cardiac death. This may be
because kidney disease causes stiffening of the arteries in the body which means that the
heart and brain are damaged by high blood pressure. By studying patients before and after
the removal of a kidney (uni-nephrectomy) for transplantation the investigators will find
out for the first time in man the effect of an isolated reduction in kidney function on the
structure and function of the arteries and heart.
Hypotheses. An isolated reduction in GFR occuring after surgical uni-nephrectomy is
associated with long term adverse cardiac and vascular effects which include:
1. Increased arterial stiffness and left ventricular mass
2. Abnormalities in left ventricular systolic and diastolic function
3. Increased oxidative stress, inflammation and collagen turnover
n/a
Observational Model: Case Control, Time Perspective: Prospective
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