Chronic Kidney Disease Clinical Trial
Official title:
Pilot Study: Effects of Hectorol (Doxercalciferol) Vitamin D Replacement on Proteinuria, PTH Level and Bone Turnover in Stable Kidney Transplant Recipients: a Single-Blind, Placebo-Controlled Study in Patients Receiving 25-OH Vitamin D3
People with kidney transplants often develop bone disease. One reason for bone disease may be overactivity of a gland in the neck called the parathyroid gland. Overactivity of the parathyroid gland may be caused by lack of Vitamin D in the body. It has recently been discovered that many patients with kidney transplants have low Vitamin D levels. The investigators are examining the effects of doxercalciferol on parathyroid hormone levels, proteinuria and bone turnover markers in people who have had a kidney transplant.
People with kidney transplants often develop bone disease. One reason for bone disease may be
overactivity of a gland in the neck called the parathyroid gland. Overactivity of the
parathyroid gland may be caused by lack of Vitamin D in the body. It has recently been
discovered that many patients with kidney transplants have low Vitamin D levels.
25-OH Vitamin D3 is now recommended to treat kidney transplant patients with low vitamin D
levels but it may not be enough to treat the parathyroid problems and bone disease.
Doxercalciferol is a form of Vitamin D that has been used to treat bone disease and
parathyroid problems in dialysis patients but has not yet been studied in patients with
kidney transplants. We are interested in seeing whether doxercalciferol given together with
25-OH Vitamin D3 will be a better treatment for the overactive parathyroid gland and bone
disease than 25-OH Vitamin D3 alone in patients with kidney transplants.
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