Chronic Kidney Disease Clinical Trial
Official title:
Chronic Kidney Disease in the Pakistani Population
The Indo-Asian developing countries are facing an epidemic of chronic diseases including
hypertension, diabetes and chronic kidney disease (CKD). Diagnosis of early CKD is essential
for institution of effective and timely prevention of its complications; costly late stage
treatment for end stage renal disease is currently an unfeasible option in these
populations. GFR estimates of kidney function provide a common reference standard for all
people and are therefore readily applicable by physicians and understood by patients.
However, the existing GFR equations yield widely discrepant results in the Indo Asian
population, and none of the currently available estimating equations have been validated in
this population.
The main objective is to develop a tool which can be used for screening subjects at high
risk for developing CKD (with hypertension and diabetes) as well as the general population.
The proposed study is being conducted at the Aga Khan University in collaboration with
Tufts-New England Medical Center and Imperial College, UK. It is a population based
cross-sectional study using a 2-stage cluster design. The study would be performed on 650
adult subjects from the general population in Karachi.
A new GFR equation specific to a Pakistani population would be developed and validated using
the gold standard of measured Insulin GFR. The performance of the new equation will be
compared to the existing ones developed in other populations with respect to bias,
precision, and accuracy.
The project is likely to contribute significantly to moving the field to kidney disease
forward, and its results are likely to have far reaching implications for understanding of
CKD and, ultimately, its prevention in Indo-Pakistani populations worldwide.
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Time Perspective: Cross-Sectional
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