Immune Response to Influenza Vaccination

Chronic Kidney Disease Clinical Trial

Official title:

Immune Response to Influenza Vaccination

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00551837
• Other study ID #: 2006-12-14
• Status: Completed
• Phase: N/A
• First received: October 30, 2007
• Last updated: October 20, 2017
• Start date: November 2006
• Est. completion date: May 2008

Study information

• Verified date: October 2017
• Source: The Cleveland Clinic
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to evaluate the immune response to a routine influenza vaccination. Influenza vaccination is given as part of routine standard of care in these individuals and is not part of the study protocol. The study will evaluate for a change in response to common antigens over time after influenza vaccination to determine if changes are related to the development of chronic rejection after solid-organ transplantation. We hypothesize that the influenza vaccine contributes to the alloreactivity of T cells verses common HLA types in the donor pool.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 82
• Est. completion date: May 2008
• Est. primary completion date: April 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Transplant recipients (lung or kidney) 18 years or older, more than 3 months after transplantation

• Transplant candidates (kidney) 18 years or older, to recieve influenza vaccination

• Healthy volunteers to receive influenza vaccination

Exclusion Criteria:

• Under 18 years of age

• Pregnant

• Medical contraindication for vaccine

• Transplant recipients receiving acute rejection therapy within one month

• Healthy volunteers with autoimmune disease or medications to mediate immune function

• Receipt of live, attenuated influenza vaccine, instead of injectable vaccine

Related Conditions & MeSH terms

• Chronic Kidney Disease
• Influenza, Human
• Kidney Diseases
• Renal Insufficiency, Chronic
• Solid Organ Transplantation

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
The Cleveland Clinic	University Hospitals Cleveland Medical Center