Chronic Kidney Disease Clinical Trial
Official title:
The Efficacy of 1,25 Dihydroxycholecalciferol on the Cardiovascular System in Patients With Renal Dysfunction
Left ventricular hypertrophy (LVH) predicts mortality at start of dialysis. Prevention of of LVH is important. It is not known whether secondary hyperparathyroidism might induce LVH. In the present study patients are randomised to 1.25 dihydroxycholecalciferol or no treatment to study the effect on LVH.
Status | Terminated |
Enrollment | 24 |
Est. completion date | December 2008 |
Est. primary completion date | December 2008 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Chronic kidney disease (S-creatinin > 150 and < 600 mikroM) - Secondary hyperparathyroidism (Between 3-8 times the upper limit of our PTH assay) - Stable blood pressure during the last 6 months (less than (160/95) - B-hemoglobin > 6 mmol/l - EKG with sinus rhythm and no sign of Q-wave infarction - Expected follow up 6 month Exclusion Criteria: - Pregnancy - Kidney transplantation - Malignant disease |
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Denmark | Department of Renal Medicne C, Skejby Hospital | Aarhus |
Lead Sponsor | Collaborator |
---|---|
Per Ivarsen |
Denmark,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The effect of dihydroxycholecalciferol on left ventricular hypertrophy | 6 month | No | |
Secondary | Changes in the activity of the renin-angiotensin system | 6 month | No | |
Secondary | Changes in left ventricular function | 6 month | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
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