Randomized Controlled Open Label Trial of Peg Alpha 2a Interferon and Adjusted-dose of Ribavirin vs. Standard Therapy in the Treatment of Naive Chronic Hepatitis C Patients Infected With Genotype 4

Chronic Hepatitis C Virus Clinical Trial

Official title:

Randomized Controlled Open Label Trial of Peg Alpha 2a Interferon and Adjusted-dose of Ribavirin vs. Standard Therapy in the Treatment of Naive Chronic Hepatitis C Patients Infected With Genotype 4

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01686789
• Other study ID #: RC08-064
• Status: Completed
• Phase: Phase 4
• First received: September 13, 2012
• Last updated: February 23, 2016
• Start date: January 2011
• Est. completion date: August 2015

Study information

• Verified date: February 2016
• Source: King Abdulaziz Medical City
• Contact: n/a
• Is FDA regulated: No
• Health authority: Saudi Arabia: Ethics CommitteeKing Abdallah International Medical Research Centre, National Guard Health Affairs, Riyadh, Saudi Arabia:
• Study type: Interventional

Clinical Trial Summary

The study aims to study the outcome of pharmacokinetics-adjusted dose ribavirin (plus pegIFN) on the SVR in chronic HCV patients.

Description:

Background: The introduction of Peg interferon and Ribavirin (an oral nucleoside analogue) for chronic Hepatitis C has led to the concept that chronic hepatitis C (HCV) is a curable disease. Improvement of treatment efficacy is still a major challenge. Optimal Ribavirin doses are essential to achieve SVR (sustained virological response). A recent trial showed significantly higher sustained virological response (SVR) in patients receiving 15.2 mg/kg/day of Ribavirin compared with 13.3 mg/kg/day. Ribavirin was given in combination with Peg interferon alpha-2b (1). A small pilot study, in which 10 patients with Chronic Hepatitis C genotype 1 were treated with Ribavirin dosage up to 3600 mg/day- mean of 2540 mg/day- plus Peg-interferon alpha-2a, achieving a target concentration of Ribavirin >15 micromol before W 12, led to 90% of SVR(2). All patients managed to complete the one year treatment period but all needed EPO and two were transfused.

Patient's global exposure to Ribavirin as evaluated by the area under the curve (AUC) seems more pertinent in terms of exposure-effect relationship than measuring Ribavirin level at any single time point. A recent study showed in HCV patients infected with genotype 1 that Ribavirin plasma exposure after the first dose (i.e., interdose AUC0-12h or abbreviated AUC0-4h) was significantly and strongly linked with SVR, whereas AUCs determined at W12 and W24 and trough concentrations at Day 0 and W12 were not (3).

Therefore, we propose a randomized controlled trial to investigate whether adjusted Ribavirin doses based on AUC0-4h obtained at D-7 after 600mg dose of Ribavirin versus fixed standard doses can improve outcome in treatment of chronic hepatitis C naïve patients infected with genotype 4.

Methodology: After AUC0-4h has been determined at D-7 (7 days before randomization) for 190 genotype 4 patients recruited into the trial, the patients are randomized into two groups: Group A: to receive standard dose of Ribavirin 1000-1200 mg/day) and Group B: to receive adjusted-dose of Ribavirin according to AUC0-4h. The individual calculated dose should be administered for each patient beginning on the first day of treatment. Both groups will receive combination treatment with peginterferon alpha 2a 180 mcg/week for a total of 48 weeks.

Both treatment groups will receive Darbepoetin if subsequent Hb is < 11 g/dl for males and females. Our main inclusion criteria will be: patients 18-70 years old with serological evidence of chronic hepatitis C and positive HCV RNA of genotype 4, with a liver biopsy within 3 years prior to recruitment. Our main exclusion criteria will be: decompensated cirrhotic patients, HBV/HIV co-infection, evidence of hepatocellular carcinoma (HCC), significant evolutive cardiovascular, pulmonary, renal or psychiatric disease, pregnancy/breast feeding or patients post liver transplantation and anemia.

Our primary outcome will be: HCV-RNA negativity 24 weeks after the end of treatment (SVR) (input adjusted dose on SVR). Our secondary outcome will be: rapid virological response (RVR), early virological response (EVR), partial early virological response (pEVR), end of treatment response (ETR), relapse after (ETR), biochemical response and safety and tolerability of high doses of Ribavirin.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 181
• Est. completion date: August 2015
• Est. primary completion date: August 2015
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

1. 18-70 years of age

2. Chronic hepatitis C documented by a detectable HCV RNA level by a PCR performed within 3 months -A liver biopsy performed within 3 years or fibro test/fibroscan within 1 year of inclusion.

3. Naive patients

4. Genotype 4

5. Compensated cirrhosis hepatitis C liver disease (Child-Pugh = 6)

6. Patient needing, according to the physician, the initiation of a combined therapy of pegylated interferon alfa plus Ribavirin

7. Negative HBsAg test and HIV-Elisa test

8. Negative pregnancy test at baseline in women in age of procreation

9. Efficient contraception all along the treatment period, and for 6 months after discontinuation of the treatment for women and men

Exclusion Criteria:

1. Decompensated Cirrhotic patients

2. HBV or HIV co-infection

3. Evidence of hepatocellular carcinoma

4. Significant and evolutive cardiovascular, pulmonary, severe psychiatric disorder or renal dysfunction (calculated creatinine CL < 50 ml/min) *. Patients who met the trial criteria if subsequent calculated creatinine CL < 50 ml/min may need ribavirin dose reduction.

5. Non compensated thyroid dysfunction

6. Recent history of epilepsy (less than 6 months)

7. Absolute contraindications to one of the drug of combination therapy

8. Any non-compensated cardiac disease including ischemic heart disease Chronic cardiac failure (grade III or IV - NYHA classification)

9. Uncontrolled high blood pressure (SBP > 180 mmHg during inclusion in spite of hypertension treatment)

10. Pregnancy or breast feeding.

11. Post liver transplantation patient with HCV

12. Alcohol or drug induced liver disease.

13. Metabolic or autoimmune liver disease.

14. Hemoglobinopathies or anemia; hemoglobin <12 gm /dl for females and <12.5 for males not corrected by erythropoietin

15. Neutropenia (<1500/mm³)

16. Thrombocytopenia (<90,000/mm3), thrombocytosis (> 500,000/mm3)

17. Patients with evolutive diabetic or hypertensive retinopathy. Patients who are stable can be included but should be regularly followed during treatment.

18. Hypersensitivity to epoetin beta or one of its excipients

19. Previous history or increased risk of venous thrombosis

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Chronic Hepatitis C Virus
• Hepatitis
• Hepatitis A
• Hepatitis C
• Hepatitis C, Chronic
• Hepatitis, Chronic

Intervention

Drug:
• Pegylated interferon alpha-2a

Locations

Country	Name	City	State
Saudi Arabia	King Abdulaziz Medical City	Riyadh
Saudi Arabia	King Faisal Specialist Hospital & Research Centre	Riyadh
Saudi Arabia	King Khaled University Hospital	Riyadh

Sponsors (1)

Lead Sponsor	Collaborator
King Abdulaziz Medical City

Country where clinical trial is conducted

Saudi Arabia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Sustained virological response	Detectability of HCV RNA after 24 weeks of treatment completion by a realTime PCR-based technique	72 weeks	No
Secondary	Requirement of blood-related products	The development of anemia or requirement of blood-related products	48 weeks	Yes