| Eligibility |
Inclusion Criteria:
- 1. Able and willing to provide written informed consent and to comply with the study
protocol according to ICH and local regulations.
2. Positive serum HBsAg and/or HBV DNA status for > 6 months prior to screening (two
documented positive HBsAg and/or HBV DNA tests at least 6 months apart, one of which
is at screening) or previous liver biopsy results with chronic HBV infection.
3. On Nucleos(t)ide analogs therapy for at least 3 months without an interruption of 7
or more consecutive days before the screening, and expected to remain on the same
Nucleos(t)ide analogs for the duration of study participation.
4. 500 = HBsAg = 3,000 IU/mL, HBV DNA = 20 IU/mL and ALT = 3×ULN. 5. A male subject
must agree to use adequate contraception from screening through at least 24 weeks
after the dose of investigational product. Refer to Section 5.5 for more information
on highly effective methods of contraception.
6. Women of childbearing potential must have a negative pregnancy test prior to the
dosing administration, and agree to use adequate contraception from screening through
at least 24 weeks after the dose of investigational product. A female subject of
non-childbearing potential will have had at least 12 continuous months of natural
(spontaneous) amenorrhoea, follicle stimulating hormone (FSH) level > 40 mIU/mL at
screening, and an appropriate clinical profile (e.g., age appropriate, history of
vasomotor symptoms); or have had surgical bilateral oophorectomy, hysterectomy or
bilateral tubal ligation beyond 6 weeks prior to screening. Refer to Section 5.5 for
more information on highly effective methods of contraception.
Exclusion Criteria:
- 1. Patients who had history of anaphylaxis against the active ingredients or
excipients of the investigational product 162.
2. History of allergic reactions to monoclonal antibodies or antibody fragments.
3. History or presence of clinical significant liver disease other than chronic HBV
infection (e.g., autoimmune hepatitis, alcoholic liver disease, non-alcoholic
steatohepatitis).
4. Patients who have impaired cardiac function or clinically significant cardiac
diseases, including any of the following: New York Heart Association class III-IV for
cardiac insufficiency; Patients with poorly controlled arrhythmia: QTc interval > 480
ms calculated by Fridericia's formula, or congenital syndrome of prolonged QT
interval; Any of the following within 6 months prior to the screening: myocardial
infarction, severe or unstable angina, congestive heart failure, cerebrovascular
accident (including transient ischemic attack), symptomatic pulmonary embolism or
other clinically significant thromboembolic disease, or coronary artery bypass graft;
Patients with other clinically significant cardiovascular disease who were assessed as
unsuitable for this study by the investigator.
5. Patients with uncontrolled hypertension (systolic blood pressure = 150 mm Hg and/or
diastolic blood pressure = 100 mm Hg) or previous hypertensive crisis or hypertensive
encephalopathy.
6. Patients with other active infections other than HBV infection requiring continual
treatment with antibiotics or antivirals (except for clinically insignificant
temporary infection such as cold), or positive for hepatitis C virus (HCV) or human
immunodeficiency virus (HIV) antibodies at screening.
7. Patients with history of hepatitis A virus (HAV), hepatitis D virus (HDV) or
hepatitis E virus (HEV).
8. Patients with history of malignant tumor within 5 years except cured basal cell
carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in situ of
uterine cervix.
9. History or presence of immune-mediated diseases, including but not limited to
idiopathic thrombocytopenic purpura, systemic lupus erythematosus, rheumatoid
arthritis.
10. Liver biopsy, Fibroscan or equivalent test obtained within the past 6 months
demonstrating liver with evidence of progressive fibrosis or cirrhosis ( Metavir 3,
recommended cut-off for fibroscan 8.5 kPa).
11. Evidence of liver cirrhosis or decompensated liver disease such as Child-Pugh
Class B or C, ascites, esophageal or gastric varices, hepatic encephalopathy or portal
hypertension.
12. History of or suspicion of hepatocellular carcinoma or alpha fetoprotein (AFP) >
50 ng/mL at screening.
13. History of allogenic transplantation of organs, bone marrow or stem cell. 14. Any
other concomitant disease, condition or treatment that could interfere with the
conduct of the study or that would, in the opinion of the Investigator or Sponsor,
pose an unacceptable risk to the subject in the study or interfere with the
interpretation of study data.
15. Those who received blood transfusion, albumin, recombinant human thrombopoietin,
or colony-stimulating factor therapy within 2 weeks prior to screening 16. Patients
who have not sufficient baseline organ function and whose laboratory data meet the
following criteria at enrollment: Absolute neutrophil count (ANC) < 2.0×109/L; Serum
albumin < 35 g/L; Total bilirubin > 1.5×ULN; International normalized ratio (INR) >
1×ULN; Hemoglobin < 100 g/L; Platelets < 80×109/L; Creatinine clearance < 50 mL/min.
17. Patients who had received an immunosuppressant, immunity-modifying drug (e.g.,
interferon, thymosin agents), cytotoxic chemotherapy that can affect their immune
system, or radiation therapy within 6 months prior to the dosing of investigational
product, except for the following treatments: a) topical or inhaled corticosteroids;
b) short-term (treatment duration up to 7 days) use of systemic glucocorticoids for
prevention or treatment of non-autoimmune allergic diseases.
18. Those who have received live or attenuated vaccines (e.g., measles, mumps,
rubella, varicella, yellow fever, rabies, BCG, typhoid vaccine, etc.) within 4 weeks
before screening, or any covid-19 vaccine within 2 weeks before screening.
19. Those who underwent major surgery within 4 weeks before screening, or plan to
undergo major surgery during the study.
20. Those who are participating in other clinical studies, or currently not
participating in a study and have been dosed in another clinical study 4 weeks prior
to screening, or previous treatment with an investigational agent for chronic HBV
infection 6 months prior to screening.
21. Pregnant or lactating women. 22. Those who are determined disqualified to join
clinical studies by investigator for other causes.
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