Chronic Hepatitis B Clinical Trial
Official title:
HBsAg Loss/Seroconversion in Low Replicative Chronic HBV Infection Patients With Low Level HBsAg Treated With Peginterferon Alpha
HBsAg Loss/Seroconversion is uncommon in Low replicative chronic HBV infection patients. The purpose of this study is to investigate the ability of peginterferon alpha to achieve HBsAg loss/seroconversion therapy in Low replicative chronic HBV infection patients with Low Level HBsAg.
Low replicative chronic HBV infection patients with low Level HBsAg were enrolled in the
out-patient department of 3rd Affiliated Hospital of Sun Yat-sen University. All of them were
HBsAg positive and anti-HBs negative for more than 6 months with HBV DNA<2000 IU/mL and HBsAg
levels ≤1000 IU/mL. All patients did not have other liver diseases and contraindications for
interferon therapy.
After giving informed consent, patients were treated with weekly subcutaneous injections of
alfa-2a 180 micrograms/week or peginterferon alfa-2b 80 micrograms/week. The use of other
immune suppressive or regulatory drugs and other antiviral drugs was prohibited during the
course of the study.
In this study, treatment endpoint was HBsAg loss(<0.05 IU/mL) and anti-HBs positive(>10
milli-International unit(mIU)/mL) defined as seroconversion. Depending on the decline of
HBsAg level, treatment was either continued for a prolonged period (no more than 96 weeks)
until the endpoint was achieved, or terminated in case of nonresponse. Treatment was
proceeded if HBsAg level continued to decline until HBsAg seroconversion was achieved and the
anti-HBs level was above 200 mIU/ml. If the patients were not willing to extend treatment,
the therapy was ended at the time of HBsAg loss, or stopped without further decline of HBsAg
levels.
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