Chronic Hepatitis B Clinical Trial
Official title:
Lowering Viral Load With Nucleos(T)Ide Analogues Prior to Peginterferon Alfa-2b Treatment to Increase Sustained Response in HBeAg-positive Chronic Hepatitis B (PEGON-study)
Treatment with a nucleoside analogue and subsequent viral decline has shown to partially
restore immune hyporesponsiveness in chronic hepatitis B patients. Recent pilot studies
investigating whether the effect of lowering viral load with nucleoside analogue therapy
prior to the initiation of peginterferon results in higher sustained off-treatment responses
showed contradictory findings.
The aim of this study is to investigate sustained off-treatment response to peginterferon
alfa-2b in chronic HBeAg-positive hepatitis B patients who are pretreated with nucleos(t)ide
analogues, thereby lowering viral load
n/a
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