SPG Neurostimulation in Cluster Patients

Status Completed

Clinical Trial Summary

We hypothesized that LF stimulation of the SPG would increase parasympathetic outflow, activate sensory afferents and provoke a cluster-like attack.

Clinical Trial Description

We conducted a double-blind, randomized, sham-controlled, crossover study to investigate cluster attack induction following LF (20 Hz and 0.2‒2.1 amplitude) and sham (amplitude = 0) stimulation in 20 CH patients with implanted SPG neurostimulator. In addition, we measured plasma concentrations of pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal peptide (VIP), as markers for parasympathetic activation before, during and after SPG stimulation. We also investigated if LF SPG stimulation induces changes in cardiac autonomic regulation and whether any attacks induced by SPG stimulation are associated with such changes. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02510729
Study type	Interventional
Source	Danish Headache Center
Contact
Status	Completed
Phase	N/A
Start date	July 2015
Completion date	October 2016

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