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Immunohistochemical Study of Chordomas to Improve Their Diagnosis and Prognosis Care — CHORDOMES  

Chordoma Clinical Trial

Official title:
Immunohistochemical Study of Chordomas to Improve Their Diagnosis and Prognosis Care

Clinical Trial Summary

Chordomas are very rare malignant tumors, chemo-resistant with high propensity for recurrence. The role of immunotherapy in these patients remains largely unexplored while PD-L1 and CD8 status in the micro-environment of chordomas is basically not known. Similarly, this tumor often poses diagnostic difficulties due to its resemblance with metastasis or chondrosarcoma, thus, it would be useful to know the expression status of factors used during the work-up of metastatic or mesenchymal tumors, like CDX2, INSM1 and FOXA1, which remains unknown for chordomas. Thus, the aim of the study is to explore PD-L1, CD8, CDX2, INSM1 and FOXA1 expression in a series of chordomas and compare it with clinico-pathological and prognostic features.

Clinical Trial Description

Retrospective, non-interventional study. A series of chordomas will be analyzed for detailed histologic features and for various immunohistochemical factors and results will be compared with clinical factors, like overall and disease-free survival. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04486820
Study type Observational
Source Centre Hospitalier Universitaire de Saint Etienne
Contact
Status Completed
Phase
Start date April 1, 2020
Completion date July 1, 2020
View Details
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