Investigating the Production of Lipoproteins and Acetyl-CoA During a Ketogenic Diet — PLAK  

Cholesterol Metabolism Clinical Trial

Official title: Investigating the Production of Lipoproteins and Acetyl-CoA During a Ketogenic Diet

Status Completed

Clinical Trial Summary

The purpose of this study is to understand how the reduction in dietary carbohydrates in a very-low carbohydrate ketogenic diet impacts the synthesis of cholesterol, fatty acid, and ketones, and the turnover rate of VLDL and chylomicron particles.

Clinical Trial Description

Participants will consume a standard American diet for one week followed by a very-low carbohydrate ketogenic diet (VLCKD, <50 grams carbohydrate/day) for two weeks. Participants will undergo an oral stable isotope tracer study during each diet to measure de novo synthesis of fatty acid, cholesterol, ketone bodies, and for measurement of apolipoprotein B and triglyceride kinetics. ;

Related Conditions & MeSH terms

• Cholesterol Metabolism
• Ketone Metabolism

• NCT number: NCT03901014
• Study type: Interventional
• Source: Touro University, California
• Status: Completed
• Phase: N/A
• Start date: March 31, 2019
• Completion date: April 18, 2019