Cholestasis Clinical Trial
OBJECTIVES:
I. Determine the role of magnesium deficiency in the pathogenesis of decreased serum vitamin
D and reduced bone density in children with chronic cholestatic liver disease.
Status | Completed |
Enrollment | 25 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 3 Years to 18 Years |
Eligibility |
PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- - Diagnosis of liver disease with chronic cholestasis Nonsyndromic intrahepatic cholestasis Alagille's syndrome Extrahepatic biliary atresia - Direct bilirubin greater than 2 mg/dL OR Bile acids greater than 20 micromoles/L - No hepatic decompensation defined as one or more of the following: Ascites Peripheral edema PT at least 4 seconds longer than control Albumin less than 3 g/dL --Patient Characteristics-- - Renal: No significant renal disease - Cardiovascular: No significant cardiovascular disease - Pulmonary: No significant pulmonary disease |
Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | Children's Hospital Medical Center - Cincinnati | Cincinnati | Ohio |
Lead Sponsor | Collaborator |
---|---|
National Center for Research Resources (NCRR) | Children's Hospital Medical Center, Cincinnati |
United States,
Heubi JE, Wiechmann DA, Creutzinger V, Setchell KD, Squires R Jr, Couser R, Rhodes P. Tauroursodeoxycholic acid (TUDCA) in the prevention of total parenteral nutrition-associated liver disease. J Pediatr. 2002 Aug;141(2):237-42. — View Citation
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