Clinical Trials Logo

Clinical Trial Summary

Laparoscopic Cholecystectomy applied to Artificial pneumoperitoneum and the extent of Surgical stimulation cause the wave of hemodynamics increase vigorously, which make it difficult to judge the depth of anesthesia according to traditional hemodynamics index such as heart rate and blood pressure.In case of this, the investigators design this research to study the Closed-Loop Target Controlled Infusion to anaesthesia of individualization guided by a Narcotrend index monitor in Laparoscopic Cholecystectomy.


Clinical Trial Description

Anesthetics alter electrocortical activity in a dose-dependent manner,and it is suggested that electroencephalographic(EEG)activity can provide a reliable basis for a surrogate measurement of hypnosis.An EEG monitor,the Narcotrend Index(NI),has proven useful to titrate hypnotic drugs.Because it is a single composite measure monitored continuously,it has been used in controlled studies to automatically guide propofol administration.Conversely,automated delivery systems for opioids have seldom been described using EEG activity There are no specific measures to quantify analgesia directly.Nevertheless,in the interaction between opioid-hypnotic synergy and loss of consciousness,when the dose of analgesic administered is sufficient to inhibit autonomic response to noxious stimuli,then the required hypnotic concentration is only that needed to achieve loss of consciousness.Moreover,a noxious stimulus such as laryngoscopy or periosteal pressure to the tibia may cause electrocortical activation with an increase in Narcotrend index,which indirectly reflects the analgesic state or the level of antinociception.Finally,an excitatory EEG arousal reaction resulting from nociceptive stimulation can provide a rational basis for analgesia administration.It can then be hypothesized that Narcotrend index could also be the controlled variable for opioid administration. ;


Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care


Related Conditions & MeSH terms


NCT number NCT02114437
Study type Interventional
Source Guangzhou General Hospital of Guangzhou Military Command
Contact bo xu
Phone 88653387
Email xubo333@hotmail.com
Status Recruiting
Phase Phase 4
Start date March 2014
Completion date March 2015

See also
  Status Clinical Trial Phase
Terminated NCT01552421 - The Effect of Transvaginal vs. Conventional Laparoscopic Cholecystectomy on the Postoperative Course N/A
Completed NCT00974194 - Safety and Cost-effectiveness Study of Single Port Laparoscopic Cholecystectomies N/A
Completed NCT01056250 - SILS Cholecystectomy: Cholangiography of the Biliary Tract N/A
Completed NCT00940264 - Laparoscopic Transvaginal Hybrid Cholecystectomy: a Prospective Data Collection. N/A
Completed NCT00370344 - Small-incision Open Cholecystectomy or Laparoscopic Cholecystectomy for Gallbladder Disease Phase 2/Phase 3
Recruiting NCT06045546 - A (5-5-5-8) Technique for Laparoscopic Cholecystectomy N/A
Recruiting NCT06035302 - Madany Closure: A Novel Technique for Fascial Closure in Laparoscopic Surgery N/A
Recruiting NCT06036303 - Nasr Fascial Closure: A Novel Device for Fascial Closure in Laparoscopic Surgery N/A
Completed NCT01824186 - Trial Comparing Pain in Single-incision Laparoscopic Cholecystectomy Versus Conventional Laparoscopic Cholecystectomy N/A
Not yet recruiting NCT00209885 - Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Phase 4
Completed NCT02116985 - Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI) Phase 4
Completed NCT00161083 - UDCA for Symptomatic Gallstone Disease Phase 4
Recruiting NCT05280860 - Effect of Bilateral RSB on Postoperative Delirium in Elderly Patients Undergoing Laparoendoscopic Single-site Surgery N/A
Completed NCT04142203 - Implementation of 23 Hour Surgery Model in a Tertiary Hospital
Completed NCT03154164 - Study on the Learning Curve for Fundus First With Ultrasonic Tissue Coagulation in Elective Cholecystectomy
Recruiting NCT03812718 - Comparison of Anaesthesia Requirement for Ventilation With Endotracheal Tube Versus Proseal Laryngeal Mask Airway N/A
Completed NCT01553331 - Day Case Laparoscopic Cholecystectomy: Fundus First With Ultrasonic Dissection or Conventional Diathermy Hook N/A
Recruiting NCT03909360 - Drainage or Not for Laparoscopic Cholecystetomy N/A
Recruiting NCT05962853 - Effect of TENS on Patient Outcomes After Laparoscopic Cholecystectomy: A Randomized Controlled Study N/A
Recruiting NCT05723224 - Elective Endoscopic Gallbladder Treatment: Pilot Study N/A