Clinical Trials Logo

Clinical Trial Summary

Compare effects of intravenous dexmedetomidine and fentanyl in attenuation of intubation response in a patient undergoing laparoscopic cholecystectomy.

Compare the effects of intravenous dexmedetomidine and fentanyl in sedation, perioperative complications, and recovery in these patients.

Dexmedetomidine is comparatively a newer drug in countries like Pakistan. There is no research work available at the national level and scarcity of data at an international level with inconclusive outcomes. Our participation in the form of this research will add to scientific literature and step up ahead at the international level.

Fentanyl citrate is a narcotic analgesic interacting predominantly with the opioid μ receptor and exerting its principal pharmacological effect on CNS. Its primary action of therapeutic value is analgesia and sedation. It is extensively used for anesthetic and analgesic most often in operating room and ICU.


Clinical Trial Description

This is double-blind, a single centered randomized clinical trial which is based on assessing the hemodynamic stability provided by our study drugs during laryngoscopy and intubation in a patient undergoing laparoscopic cholecystectomy. In addition to that this study will assess the perioperative complication and postoperative recovery in these patients. Laparoscopy has now become the standard technique of choice for cholecystectomy which results in pathophysiological changes characterized by an increase in arterial pressure and heart rate (HR). Many types of research have been done in an attempt to minimize adverse effects by adding adjuvants to the conventional method of general anesthesia. Our research is also based on this aim. The objective of this study to determine the hemodynamic stability during laryngoscopy and intubation, peri-operative complication and post-operative recovery. The patients will be divided into two groups randomly and will be given the desired drugs via intravenous line by on floor consultant anesthetist who will be blinded to the drug. The study subjects' hemodynamics will be observed until 10 minutes of intubation. Any perioperative complication will be noted. The subjects will also be followed postoperatively in recovery to check there sedation score and recovery (Aldrete score) will be noted after 10 minutes after the patient shifted to recovery. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04089592
Study type Interventional
Source Dow University of Health Sciences
Contact
Status Completed
Phase N/A
Start date January 15, 2019
Completion date July 15, 2019

See also
  Status Clinical Trial Phase
Completed NCT04852016 - Optimizing the Consent Process for Emergent Laparoscopic Cholecystectomy N/A
Withdrawn NCT00979186 - A Trial to Evaluate Natural Orifice Transgastric Endoscopic Cholecystectomy With Laparoscopic Assistance N/A
Recruiting NCT06058195 - Comparison of Quadratus Lumborum and Transverse Abdominis Plane Blocks With Intravenous Analgesic in Gallbladder Surgery
Enrolling by invitation NCT02983474 - Korea Surgical Quality Improvement Program N/A
Recruiting NCT05089526 - Opioid-free Anesthesia in Laparoscopic Cholecystectomies N/A
Completed NCT04300985 - Magnesium Sulfate Versus Dexmedetomidine on Anesthesia Awakening. Phase 3
Recruiting NCT03817541 - Expiratory and Plasma Propofol Concentration in Gastrological Surgery Patients N/A
Completed NCT03577873 - RCT on Necessity of Cholecystectomy for Patients After Clearance of Bile Duct Stones N/A
Completed NCT04270357 - Surgical Practices in Algeria : the Cholecystectomy
Completed NCT00689663 - Laparoscopic Cholecystectomy - Fundus First and Harmonic Ace Compared With Conventional Technique N/A
Recruiting NCT06447545 - Comparison Between Low Pressure Pneumoperitoneum With High Pressure Pneumoperitoneum in Post-operative Pain, Shoulder Tip Pain and Common Bile Duct Injuries in Patients Undergoing Laparoscopic Cholecystectomy N/A
Completed NCT03510923 - Selective Rather Than Routine Histopathological Examination Following Appendectomy and Cholecystectomy
Completed NCT03329859 - Microcomplications in Lap. Cholecystectomy: Reducing Intraoperative Interruptions by High Resolution Standardization N/A
Terminated NCT02163239 - Post Market Study for FloShield 10mm Reusable Cannula and Blunt Obturator and Robotic FloShield N/A
Completed NCT02085902 - Does the Use of Ropivacaine Facilitates Cholecystectomy by Laparoscopy in Ambulatory Surgery? Phase 4
Completed NCT06468735 - The Relationship Among Sarcopenia, Preperitoneal Fat Thickness and Cholecystectomy N/A
Completed NCT05681338 - Effect of the Coughing Technique During Subcutaneous Heparin Injection N/A
Completed NCT06020768 - The Effect of Different Bed-Head Angles on the Haemodynamic Parameters of Intensive Care Patients Lying in the Supine Position N/A
Completed NCT01211743 - Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy Phase 4
Completed NCT06028061 - Evaluation of Effectivity of Quadratus Lumborum Blocks With Adjuvant N/A