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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT04807712
Other study ID # ACT0606
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date May 30, 2001
Est. completion date January 1, 2030

Study information

Verified date January 2024
Source Association Clinique Thérapeutique Infantile du val de Marne
Contact Corinne Levy, MD
Phone 0033148850404
Email corinne.levy@activ-france.fr
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Since 2002, Whooping cough surveillance in pediatric private practice has been set up in France. The results of the first years, 2002-2006, have confirmed the effectiveness of the Pertussis whole-cell (Pw) vaccine and in particular the duration of protection of 9/10 years. After evaluating cases in children vaccinated with Pw vaccines, the study aims today to analyze cases in children vaccinated with Pertussis acellular (Pa) vaccines used since 2002/2003 and to assess, on an outpatient basis, the impact of new vaccine recommendations in France (in 2013, introduction of a 2 + 1 schedule - 8 weeks, 4 months and a 11-month recall - and a 6-year recall, and in 2014, update in the recommendations of exams to be prescribed based on the child's age and vaccination status).


Description:

The whooping cough surveillance objectives are : - to follow the duration of protection of the Ca vaccines in the context of modifications of the vaccine recommendations - to describe the clinical characteristics of a population vaccinated with several boosters - to adapt complementary examinations for diagnostic purposes (culture, PCR, serology) according to the evolution of scientific knowledge - to monitor B. parapertussis infections - to train laboratories with nasopharyngeal aspiration - to monitor the evolution of the bacterial species All children aged 0-18 years, in whom the diagnosis of pertussis is mentioned and for which a biological check-up is requested, are included, except asymptomatic children with confirmed family case. In case of suspected pertussis, real-time PCR and / or culture and / or (rarely) serology is / are still prescribed to the patient and / or his entourage. Selected Pediatricians from the ACTIV group and the AFPA working in an outpatient clinic, located in different places in France, are participating in this network since 2001. The clinical evolution and the results of the examinations are transcribed on a case report form. The data are collected, firstly, during the visit where the diagnosis of whooping cough is suspected and a biological assessment requested (patient's medical history, clinical data, vaccination status and dates, as well as the search for a contaminated/contaminator) and secondly during the follow-up visit (results of the biological check-up and diagnosis, antibiotics potentially prescribed, and supplement data of the entourage, except in case of diagnosis of pertussis not retained). All evaluations made by the pediatricians are regularly reviewed during meetings, and final diagnoses used are: - biological pertussis - epidemiological pertussis - not evaluable - lost of follow up - no whooping cough


Recruitment information / eligibility

Status Recruiting
Enrollment 898
Est. completion date January 1, 2030
Est. primary completion date January 1, 2030
Accepts healthy volunteers
Gender All
Age group 1 Day to 18 Years
Eligibility Inclusion Criteria: - All children under 18 years old with a pertussis diagnosis is suspected and a biological exam is requested Exclusion Criteria: - children without symptoms with a household confirmed case - cases for which the pertussis diagnosis was not suspected by the pediatrician

Study Design


Intervention

Other:
non interventional study


Locations

Country Name City State
France ACTIV Créteil

Sponsors (4)

Lead Sponsor Collaborator
Association Clinique Thérapeutique Infantile du val de Marne GlaxoSmithKline, Merck Sharp & Dohme LLC, Sanofi

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary Duration of pertussis vaccines protection Evaluate the duration of protection of the Ca vaccines at inclusion
Secondary Clinical characteristics of pertussis Describe the clinical characteristics of a population vaccinated at inclusion
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